| August |
| | 21 | 7:00PM | Robert Morris College | @ | University of Illinois at Springfield | 1-1 | |
| | 23 | | Crichton College | @ | Harris-Stowe | 1-1 | |
| | 24 | 2:30PM | Indiana Wesleyan University | vs. | University of Illinois at Springfield | 3-1 | |
| | Judson Tourney |
| | 25 | 2:00PM | Taylor University | vs. | University of Illinois at Springfield | 2-0 | |
| | 26 | 12:00PM | Robert Morris College | @ | Harris-Stowe | 1-2 | |
| | | 7:00PM | Columbia | @ | Grand View College | 1-2 | (2OT) |
| | 28 | 2:00PM | Freed-Hardeman | @ | Williams Baptist | 0-3 | |
| | 30 | | Iowa Wesleyan College | @ | Hannibal-LaGrange | 1-2 | |
| | | 7:00PM | Missouri Valley College | @ | Harris-Stowe | 5-1 | |
| | 31 | 9:00PM | Missouri Valley College | @ | Missouri Baptist | 0-1 | |
| | | 9:00PM | William Woods | @ | Graceland University | 0-5 | |
| September |
| | 1 | 12:00PM | McKendree | @ | MacMurray College | 22-0 | |
| | | 5:00PM | William Jewell College | @ | Hannibal-LaGrange | 4-1 | |
| | | 7:00PM | Trinity International University | @ | Missouri Baptist | 0-1 | |
| | | 8:30PM | Lindsey Wilson | @ | University of Illinois at Springfield | 3-0 | |
| | | 9:00PM | Hastings College | @ | Columbia | 2-1 | |
| | 2 | 3:00PM | Westminster College | vs. | McKendree | 1-2 | |
| | | 4:00PM | Lyon College | @ | Harris-Stowe | 4-0 | |
| | | 7:45PM | Dakota Wesleyan University | @ | University of Illinois at Springfield | 0-4 | |
| | 4 | 7:00PM | Central Methodist College | @ | Missouri Baptist | 1-2 | |
| | | 9:30PM | Columbia | @ | Lindenwood University | 0-1 | |
| | 5 | 4:00PM | McKendree | @ | Missouri Valley College | 0-1 | |
| | | 6:00PM | Goshen College | @ | University of Illinois at Springfield | 0-1 | |
| | 7 | 3:00PM | Williams Baptist | @ | Central Methodist College | 1-2 | |
| | | 6:00PM | Hannibal-LaGrange | @ | Baker University | 1-3 | |
| | | 9:00PM | Bellevue University | @ | Columbia | 2-1 | |
| | 8 | | Hannibal-LaGrange | @ | MidAmerica Nazarene University | 2-1 | |
| | | 5:00PM | Culver-Stockton College | @ | William Woods | 2-1 | |
| | | 5:30PM | Missouri Baptist | @ | University of the Ozarks | 1-2 | |
| | | 7:00PM | Faulkner University | @ | Harris-Stowe | 1-4 | |
| | | 9:00PM | Graceland University | @ | Columbia | 3-1 | |
| | 9 | 3:00PM | Brescia University | @ | McKendree | 0-3 | |
| | Marion College Invitational Tournament |
| | | 4:00PM | Harris-Stowe | @ | Spring Hill College | 2-3 | |
| | First Annual Spring Hill College Soccer Invitational |
| | 10 | 7:00PM | William Woods | @ | Missouri Valley College | 0-4 | |
| | 11 | 7:00PM | University of Illinois at Springfield | @ | Illinois Institute of Technology | 0-2 | |
| | | 9:00PM | Lindenwood University | @ | Missouri Baptist | 0-2 | |
| | 13 | 6:00PM | Bacone College | @ | Williams Baptist | 2-1 | |
| | 14 | 1:30PM | Asbury College | vs. | Columbia | 2-1 | |
| | Judson College (IL) Tournament |
| | | 2:00PM | Union University | @ | Missouri Baptist | 0-1 | |
| | | 3:00PM | University of Illinois at Springfield | @ | Lyon College | 2-0 | |
| | | 5:00PM | Hannibal-LaGrange | @ | Southern Nazarene University | 0-4 | |
| | | 5:00PM | Friends University | @ | William Woods | 6-0 | |
| | | 6:00PM | Benedictine College | @ | Harris-Stowe | 9-1 | |
| * | 15 | 1:00PM | University of Illinois at Springfield | @ | Williams Baptist | 3-0 | |
| | First American Midwest Conference game of the season |
| | | 2:00PM | Lee University | @ | Missouri Baptist | 4-0 | |
| | | 3:00PM | McKendree | @ | Ottawa University | 5-0 | |
| | | 4:00PM | Columbia | @ | Judson College | 2-1 | |
| | Judson University Tournament |
| | | 5:00PM | Hannibal-LaGrange | @ | Oklahoma City University | 2-3 | |
| | 16 | 12:00PM | Benedictine College | @ | McKendree | 3-4 | |
| | McKendree scores four unanswered goals for comeback 4-3 win |
| | | 3:00PM | Harris-Stowe | @ | Culver-Stockton College | 1-3 | |
| * | 17 | 1:00PM | McKendree | @ | Williams Baptist | 7-0 | |
| * | 18 | 7:00PM | William Woods | @ | Missouri Baptist | 2-3 | |
| * | 19 | 6:00PM | Columbia | @ | Hannibal-LaGrange | 1-2 | |
| * | | 7:00PM | Harris-Stowe | @ | University of Illinois at Springfield | 2-5 | |
| | 21 | | William Woods | @ | Central Methodist College | 0-1 | |
| | | 4:00PM | Missouri Baptist | @ | MidAmerica Nazarene University | 0-3 | |
| * | | 4:00PM | Harris-Stowe | @ | Williams Baptist | 2-4 | |
| | 22 | 2:00PM | Columbia | @ | Baker University | 1-3 | |
| | | 7:00PM | Missouri Baptist | @ | William Jewell College | 0-2 | |
| | | 7:00PM | Missouri Valley College | @ | University of Illinois at Springfield | 0-3 | |
| | | 8:00PM | Hannibal-LaGrange | @ | Azusa Pacific University | 0-1 | (2OT) |
| | 23 | 5:00PM | Culver-Stockton College | @ | McKendree | 0-7 | |
| | McKendree's Tim Dew records hat trick in the win |
| | 24 | | Hannibal-LaGrange | vs. | Point Loma Nazarene University | 0-1 | |
| | at Azusa Pacific |
| | | 6:00PM | Williams Baptist | @ | Crichton College | 1-4 | |
| * | 26 | 4:00PM | Missouri Baptist | @ | Hannibal-LaGrange | 0-3 | |
| * | | 6:00PM | William Woods | @ | Harris-Stowe | 2-1 | |
| * | | 7:00PM | University of Illinois at Springfield | @ | Columbia | 1-3 | |
| | 28 | 7:00PM | Harris-Stowe | @ | Freed-Hardeman | 1-0 | (2OT) |
| * | | 9:00PM | Williams Baptist | @ | Columbia | 1-5 | |
| * | 29 | | Williams Baptist | @ | William Woods | 2-3 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | University of Illinois at Springfield | 0-1 | |
| | | 7:00PM | Missouri Baptist | @ | Graceland University | 0-6 | |
| * | 30 | 7:00PM | Harris-Stowe | @ | McKendree | 1-3 | |
| October |
| * | 3 | 8:00PM | Missouri Baptist | @ | McKendree | 0-1 | |
| * | 4 | | William Woods | @ | Columbia | 1-3 | |
| | | 4:00PM | Culver-Stockton College | @ | Hannibal-LaGrange | 0-6 | |
| | | 7:00PM | Greenville College | @ | McKendree | 0-8 | |
| * | 6 | 3:00PM | Harris-Stowe | @ | Hannibal-LaGrange | 2-6 | |
| | | 7:00PM | Baker University | @ | Missouri Baptist | 2-1 | |
| * | | 7:00PM | William Woods | @ | University of Illinois at Springfield | 1-7 | |
| | | 8:00PM | McKendree | @ | Central Methodist College | 5-0 | |
| * | 9 | 7:00PM | McKendree | @ | Columbia | 2-1 | (2OT) |
| | | 9:30PM | William Woods | @ | William Jewell College | 1-8 | |
| * | 10 | 7:00PM | University of Illinois at Springfield | @ | Missouri Baptist | 1-2 | |
| * | 12 | 3:00PM | Missouri Baptist | @ | Harris-Stowe | 2-1 | |
| * | | 5:00PM | Hannibal-LaGrange | @ | McKendree | 0-2 | |
| * | 13 | 1:00PM | Missouri Baptist | @ | Williams Baptist | 3-1 | |
| | | 5:00PM | Berry College | @ | Columbia | RAIN | |
| * | 15 | | Columbia | @ | Harris-Stowe | 3-0 | |
| | | 7:00PM | University of Illinois at Springfield | @ | North Park University | 1-2 | |
| * | 17 | 5:00PM | Hannibal-LaGrange | @ | William Woods | 2-1 | |
| * | | 7:00PM | Columbia | @ | Missouri Baptist | 2-0 | |
| * | 18 | 7:00PM | McKendree | @ | University of Illinois at Springfield | 2-1 | (2OT) |
| | McKendree clinches AMC regular-season championship |
| | | 7:00PM | Harris-Stowe | @ | Fontbonne College | 2-4 | |
| * | 20 | 2:00PM | McKendree | @ | William Woods | 4-0 | |
| * | | 3:00PM | Williams Baptist | @ | Hannibal-LaGrange | 1-3 | |
| | 21 | | Avila College | @ | William Woods | 2-0 | |
| | | 1:30PM | University of Illinois at Springfield | @ | Saint Xavier University | 3-2 | |
| | | 7:00PM | Columbia | @ | Westminster College | 5-1 | |
| | 22 | 8:00PM | McKendree | @ | Lindenwood University | 0-0 | |
| | 23 | 5:00PM | Williams Baptist | @ | Lyon College | 1-2 | |
| | | 9:00PM | Mid-Continent College | @ | Columbia | 0-1 | |
| | 24 | 3:00PM | Harris-Stowe | @ | Southern Indiana | 0-4 | |
| | | 7:30PM | Missouri-St. Louis | @ | McKendree | 0-2 | |
| | University of Missouri-St. Louis |
| | 25 | 5:00PM | Hannibal-LaGrange | @ | Truman State University | 0-0 | (2OT) |
| | 2OT |
| * | 30 | 1:00PM | University of Illinois at Springfield | @ | Hannibal-LaGrange | 2-1 | |
| | Semifinal of the AMC Play-In |
| | | 7:00PM | Missouri Baptist | @ | Columbia | 3-3 | (2OT) |
| | Missouri Baptist win 3-1 on PK's |
| November |
| | 1 | 7:00PM | University of Illinois at Springfield | vs. | Missouri Baptist | 2-0 | |
| | played at Christian Brothers College High School |
| | 3 | 12:00PM | University of Illinois at Springfield | @ | Benedictine College | 0-1 | |
| | First round of the Region V Regional Tournament |
| | 6 | 7:00PM | Benedictine College | @ | McKendree | 2-0 | |
| | NAIA Region V Tournament -- Semifinals |
