| November |
| | 1 | 7:00PM | Park University | @ | Columbia | 65-71 | |
| | | 7:00PM | Hannibal-LaGrange | @ | Iowa Wesleyan College | 47-83 | |
| | 2 | 7:30PM | Illinois at Springfield | vs. | Morningside College | 55-89 | |
| | Jim Fox Invitational Tournament @ St. Ambrose University, Davenport, IA |
| | 3 | 11:00AM | Missouri Baptist | @ | Grace College | 65-80 | |
| | | 1:00PM | Illinois at Springfield | vs. | Trinity International University | 77-66 | |
| | Jim Fox Invitational at St. Ambrose University, Davenport, IA |
| | | 2:00PM | Harris-Stowe | @ | Union University | 52-87 | |
| | | 2:00PM | Blue Mountain College | @ | Williams Baptist | 60-73 | |
| | | 5:00PM | Culver-Stockton College | @ | Hannibal-LaGrange | 55-53 | |
| | Homecoming |
| | | 7:00PM | Park University | @ | McKendree | 70-61 | |
| | 6 | 5:30PM | Williams Baptist | @ | Central Babtist College | 71-43 | |
| | | 6:00PM | William Woods | @ | Central Methodist College | 74-78 | |
| | | 6:00PM | Hannibal-LaGrange | @ | Lindenwood University | 47-56 | |
| | 7 | 6:30PM | McKendree | @ | Georgetown College | 63-76 | |
| | 9 | | Hannibal-LaGrange | @ | Campbellsville University | 60-87 | |
| | | 2:00PM | Williams Baptist | vs. | Cumberland College | 56-67 | |
| | | 6:00PM | Columbia | vs. | Union University | 71-99 | |
| | Lambuth Classic | |
| | | 7:00PM | Saint Ambrose University | @ | Illinois at Springfield | 96-62 | |
| | | 8:00PM | William Woods | @ | University of Sioux Falls | 30-86 | |
| | University of Sioux Falls Classic |
| | 10 | 12:00PM | Williams Baptist | vs. | Biola University | 48-64 | |
| | McKenzie Rotary Club Classic |
| | | 1:00PM | Harris-Stowe | @ | Freed-Hardeman | 63-67 | |
| | | 2:00PM | William Woods | vs. | Northwestern College | 56-100 | |
| | University of Sioux Falls Classic |
| | | 2:00PM | Hannibal-LaGrange | @ | Lindsey Wilson | 63-79 | |
| | | 3:00PM | William Penn College | @ | Missouri Baptist | 72-78 | |
| | MBU Homecoming |
| | | 4:00PM | Columbia | @ | Lambuth University | 73-59 | |
| | | 7:00PM | Saint Xavier University | @ | McKendree | 84-77 | |
| | 12 | 7:00PM | Lincoln University | @ | McKendree | 54-64 | |
| | 13 | 5:30PM | College of the Ozarks | @ | William Woods | 98-52 | |
| | | 5:30PM | Vennard College | @ | Hannibal-LaGrange | 22-74 | |
| | | 6:00PM | Lyon College | @ | Williams Baptist | 42-40 | |
| | | 7:00PM | Illinois at Springfield | @ | Stephens College | 64-43 | |
| | | 7:30PM | Missouri Baptist | @ | Central Methodist College | 78-74 | |
| | 14 | 7:00PM | Lindenwood University | @ | McKendree | 54-62 | |
| | 15 | 5:30PM | Missouri Baptist | @ | Malone College | 68-71 | |
| | Pioneer Classic |
| | | 7:00PM | Bacone College | @ | Columbia | 47-73 | |
| | 16 | 2:00PM | Roberts Wesleyan College | vs. | Missouri Baptist | 70-66 | |
| | Pioneer Classic |
| | | 5:00PM | Harris-Stowe | vs. | St. Mary's | 78-69 | |
| | Central Missouri State Tournament |
| | | 7:00PM | McKendree | @ | Culver-Stockton College | 44-60 | |
| | | 8:00PM | Williams Baptist | @ | Texas Wesleyan | 51-58 | |
| | 17 | 2:00PM | Central Methodist College | @ | Hannibal-LaGrange | 59-41 | |
| | | 2:00PM | Williams Baptist | vs. | Jarvis Christian College | 61-59 | |
| | | 2:00PM | Columbia | @ | Lyon College | 66-69 | |
| | | 5:00PM | Harris-Stowe | vs. | Southern Illinois-Edwardsville | 61-71 | |
| | Central Missouri State Tournament |
| | | 5:15PM | Illinois at Springfield | @ | Southern Indiana | 50-90 | |
| | 18 | 2:00PM | Indiana University Southeast | @ | Harris-Stowe | 47-72 | |
| | 19 | 7:00PM | Lambuth University | @ | Columbia | 93-79 | |
| | | 7:00PM | Missouri-St. Louis | @ | McKendree | 57-70 | |
| | 20 | 5:00PM | Saint Louis College of Pharmacy | @ | Missouri Baptist | 41-96 | |
| | | 6:00PM | Illinois at Springfield | @ | Bethel College | 55-84 | |
| | | 6:00PM | Lincoln University | @ | William Woods | 72-60 | |
| | | 7:00PM | Hannibal-LaGrange | @ | Illinois College | 45-85 | |
| | 23 | | Columbia | @ | St. Gregory | 61-69 | |
| | | 7:30PM | McKendree | @ | Lindsey Wilson | 85-83 | (2OT) |
| | | 8:00PM | Harris-Stowe | @ | Oklahoma City University | 56-49 | |
| | Oklahoma City Thanksgiving Tournament |
| | 24 | 1:00PM | McKendree | @ | Campbellsville University | 70-69 | (OT) |
| | | 4:00PM | Columbia | @ | Oklahoma Baptist University | 62-63 | |
| | | 6:00PM | Harris-Stowe | vs. | University of Science and Arts | 73-64 | |
| | Oklahoma City Thanksgiving Tournament |
| | 27 | 5:30PM | Iowa Wesleyan College | @ | Hannibal-LaGrange | 60-53 | |
| | | 5:30PM | McKendree | @ | Olivet Nazarene University | 86-97 | |
| | | 6:00PM | Williams Baptist | @ | Blue Mountain College | 65-73 | |
| | | 7:00PM | Columbia | @ | Missouri Valley College | 54-67 | |
| | | 7:30PM | Illinois at Springfield | @ | Truman State University | 63-88 | |
| | 29 | 5:00PM | Missouri Baptist | @ | Park University | 70-74 | |
| | | 6:00PM | Williams Baptist | @ | Lyon College | 45-66 | |
| | | 7:00PM | Stephens College | @ | Illinois at Springfield | 58-83 | |
| December |
| | 1 | 2:00PM | Illinois at Springfield | @ | Robert Morris College | 62-74 | |
| | | 2:00PM | Hannibal-LaGrange | @ | Park University | 43-62 | |
| | | 3:00PM | Philander Smith College | @ | Williams Baptist | 55-84 | |
| | | 4:00PM | St. Louis College of Pharmacy | @ | Harris-Stowe | 34-88 | |
| | | 6:00PM | Missouri Baptist | @ | Southwest Baptist | 75-104 | |
| | 3 | 6:00PM | Harris-Stowe | @ | Southwest Baptist | 67-79 | |
| | 4 | 6:00PM | Lindenwood University | @ | Hannibal-LaGrange | 66-44 | |
| | | 7:00PM | Brescia University | @ | Columbia | 72-74 | (OT) |
| | 5 | 7:00PM | McKendree | @ | Millikin University | 60-67 | |
| | 6 | 7:00PM | Illinois at Springfield | @ | Kentucky Wesleyan College | 60-91 | |
| | 7 | 5:30PM | Waldorf College | @ | Hannibal-LaGrange | 63-49 | |
| | | 6:00PM | Williams Baptist | @ | Philander Smith College | 64-67 | |
| | | 7:00PM | Washington University | @ | McKendree | 49-76 | |
| | Bearcats defeat NCAA Division III pre-season No. 1 squad |
| | 8 | 1:00PM | Williams Baptist | @ | Oklahoma Wesleyan University | 69-62 | |
| | | 2:00PM | William Woods | @ | Stephens College | 57-70 | |
| | | 2:00PM | Columbia | @ | John Brown University | 68-77 | |
| | | 2:00PM | Missouri Baptist | @ | St. Mary-of-the-Woods College | 87-67 | |
| | | 5:15PM | Illinois at Springfield | @ | Illinois Wesleyan | 62-97 | |
| | Illinois Wesleyan nationally ranked #10 USAToday/ESPN NCAA D3 Coaches Poll |
| | | 5:30PM | Harris-Stowe | @ | Emporia State University | 58-51 | |
| | 12 | 6:00PM | William Penn College | @ | William Woods | 85-63 | |
| | 14 | 6:00PM | Hannibal-LaGrange | @ | Trinity Christian College | 80-83 | (OT) |
| | Trinity Christian College Classic |
| | | 8:00PM | Missouri Baptist | @ | Johnson & Wales University | 72-49 | |
| | 15 | 1:00PM | Hannibal-LaGrange | vs. | Bethel College | 61-66 | |
| | Trinity Christian College Classic |
| | | 2:00PM | Indiana University Northwest | @ | Illinois at Springfield | 0-2 | |
| | Indiana Northwest forfeits the game |
| | | 3:00PM | Missouri Baptist | @ | Saint Thomas University | 61-69 | (OT) |
| | 16 | 2:00PM | Quincy University | @ | Illinois at Springfield | 94-73 | |
| | 17 | 2:00PM | Columbia | @ | Park University | 68-69 | |
| | | 5:00PM | Harris-Stowe | @ | Missouri-St. Louis | 84-70 | |
| | | 6:00PM | William Woods | @ | Southwest Baptist | 46-93 | |
| | 18 | 7:00PM | Harris-Stowe | vs. | Lindsey Wilson | 70-65 | |
| | Campbellsville Tournament |
| | 19 | 2:00PM | Harris-Stowe | vs. | Campbellsville University | 59-70 | |
| | Campbellsville Tournament |
| % | | 5:30PM | Illinois at Springfield | @ | Southern Illinois-Edwardsville | 0-0 | |
| | Exhibition game (85-58 UIS loss) |
| | 28 | 1:30PM | Illinois at Springfield | vs. | Davenport University | 88-91 | |
| | @Clark University Tournament, Dec 27-31, 2007 |
| | | 2:00PM | William Woods | vs. | Concordia University | 65-90 | |
| | Columbia College Tournament |
| | | 6:00PM | Lyon College | @ | Columbia | 74-83 | |
| | 29 | | Lyon College | vs. | William Woods | 88-56 | |
| | Columbia College Tournament |
| | | | Illinois at Springfield | vs. | Mount Mercy College | 72-56 | |
| | @Clarke College Holiday Tournament |
| | | 3:00PM | Missouri Baptist | @ | Webster University | 64-67 | |
| | | 6:00PM | Concordia University | @ | Columbia | 91-63 | |
| | 30 | 1:00PM | Illinois at Springfield | vs. | Blackburn College | 74-59 | |
| | @Clarke College Holiday Tournament, Dubuque, IA |
| January |
| | 3 | 3:00PM | Missouri Baptist | @ | Southern Illinois-Edwardsville | 68-104 | |
| | | 7:00PM | McKendree | @ | Brescia University | 54-66 | |
| | 4 | 1:00PM | Harris-Stowe | @ | Saint Xavier University | 64-80 | |
| | | 7:30PM | William Woods | @ | College of the Ozarks | 57-90 | |
| | Subway- |
| | 5 | 1:00PM | William Woods | vs. | Central Babtist College | 88-75 | |
| | College of the Ozarks Tournament |
| | | 2:00PM | Williams Baptist | @ | Christian Brothers University | 51-79 | |
| | | 2:00PM | McKendree | @ | Park University | 66-57 | |
| | | 2:00PM | Cumberland College | @ | Columbia | 76-63 | |
| | | 4:00PM | Hannibal-LaGrange | @ | University of Saint Francis | 49-92 | |
| | | 5:00PM | Harris-Stowe | @ | Indiana University Northwest | 118-18 | |
| | 7 | 6:00PM | Williams Baptist | @ | Philander Smith College | 51-79 | |
| * | 8 | 7:00PM | Illinois at Springfield | @ | Williams Baptist | 61-55 | |
| * | | 7:00PM | William Woods | @ | McKendree | 70-79 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | Missouri Baptist | 60-85 | |
| * | | 7:00PM | Harris-Stowe | @ | Columbia | 75-72 | |
| * | 12 | 2:00PM | Harris-Stowe | @ | Illinois at Springfield | 81-77 | (OT) |
| * | | 2:00PM | William Woods | @ | Hannibal-LaGrange | 84-63 | |
| * | | 2:00PM | McKendree | @ | Williams Baptist | 59-45 | |
| * | | 2:00PM | Columbia | @ | Missouri Baptist | 94-82 | |
| * | 15 | 7:00PM | Illinois at Springfield | @ | McKendree | 58-71 | |
| * | | 7:00PM | Missouri Baptist | @ | William Woods | 82-78 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | Harris-Stowe | 61-79 | |
| * | | 7:00PM | Williams Baptist | @ | Columbia | 68-103 | |
| * | 19 | 2:00PM | Columbia | @ | Illinois at Springfield | 69-58 | |
| * | | 2:00PM | William Woods | @ | Harris-Stowe | 65-85 | |
| * | | 2:00PM | Williams Baptist | @ | Hannibal-LaGrange | 62-49 | |
| * | | 2:00PM | Missouri Baptist | @ | McKendree | 66-73 | |
| * | 22 | 7:00PM | Illinois at Springfield | @ | William Woods | 80-68 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | Columbia | 45-74 | |
| * | | 7:00PM | McKendree | @ | Harris-Stowe | 63-67 | |
| * | | 7:00PM | Missouri Baptist | @ | Williams Baptist | 65-52 | |
| | 24 | 7:00PM | Brescia University | @ | McKendree | 50-72 | |
| * | 26 | 2:00PM | Illinois at Springfield | @ | Hannibal-LaGrange | 75-65 | |
| * | | 2:00PM | William Woods | @ | Williams Baptist | 46-71 | |
| * | | 2:00PM | Columbia | @ | McKendree | 58-78 | |
| * | | 4:00PM | Harris-Stowe | @ | Missouri Baptist | 70-62 | |
| | 28 | 6:00PM | Central Babtist College | @ | Williams Baptist | 59-70 | |
| * | 29 | 7:00PM | Missouri Baptist | @ | Illinois at Springfield | 74-76 | |
| * | | 7:00PM | Columbia | @ | William Woods | 81-60 | |
| * | | 7:00PM | McKendree | @ | Hannibal-LaGrange | 85-61 | |
| * | | 7:00PM | Williams Baptist | @ | Harris-Stowe | 64-67 | |
| February |
| * | 2 | 2:00PM | Williams Baptist | @ | Illinois at Springfield | 59-57 | |
| * | | 2:00PM | McKendree | @ | William Woods | 86-70 | |
| * | | 2:00PM | Missouri Baptist | @ | Hannibal-LaGrange | 84-66 | |
| * | | 2:00PM | Columbia | @ | Harris-Stowe | 54-69 | |
| * | 5 | 7:00PM | Illinois at Springfield | @ | Harris-Stowe | 57-81 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | William Woods | 57-76 | |
| * | | 7:00PM | Williams Baptist | @ | McKendree | 51-68 | |
| * | | 7:00PM | Missouri Baptist | @ | Columbia | 63-77 | |
| * | 9 | 2:00PM | McKendree | @ | Illinois at Springfield | 78-67 | |
| * | | 2:00PM | William Woods | @ | Missouri Baptist | 63-76 | |
| * | | 2:00PM | Harris-Stowe | @ | Hannibal-LaGrange | 78-39 | |
| * | | 2:00PM | Columbia | @ | Williams Baptist | 83-50 | |
| * | 12 | 7:00PM | Illinois at Springfield | @ | Columbia | 81-83 | |
| * | | 7:00PM | Harris-Stowe | @ | William Woods | 71-59 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | Williams Baptist | 43-61 | |
| * | | 7:00PM | McKendree | @ | Missouri Baptist | 78-71 | |
| | McKendree's Heather Elders surpasses 1,000-point mark for her career in the win |
| | 14 | 5:00PM | Park University | @ | Missouri Baptist | 89-68 | |
| * | 16 | 2:00PM | William Woods | @ | Illinois at Springfield | 64-68 | |
| * | | 2:00PM | Columbia | @ | Hannibal-LaGrange | 87-69 | |
| * | | 2:00PM | Harris-Stowe | @ | McKendree | 50-72 | |
| | McKendree holds Harris-Stowe to 32.3% shooting for the game |
| * | | 2:00PM | Williams Baptist | @ | Missouri Baptist | 70-74 | (OT) |
| * | 19 | 7:00PM | Hannibal-LaGrange | @ | Illinois at Springfield | 47-72 | |
| * | | 7:00PM | Williams Baptist | @ | William Woods | 51-60 | |
| * | | 7:00PM | Missouri Baptist | @ | Harris-Stowe | 85-83 | (OT) |
| * | | 7:00PM | McKendree | @ | Columbia | 67-61 | |
| * | 23 | 2:00PM | Illinois at Springfield | @ | Missouri Baptist | 59-68 | |
| * | | 2:00PM | William Woods | @ | Columbia | 70-96 | |
| * | | 2:00PM | Hannibal-LaGrange | @ | McKendree | 55-72 | |
| * | | 2:00PM | Harris-Stowe | @ | Williams Baptist | 74-46 | |
| * | 29 | 7:00PM | Williams Baptist | @ | Columbia | 55-102 | |
| | American Midwest Conference Tournament Quarterfinals |
| | | 7:00PM | Hannibal-LaGrange | @ | McKendree | 37-84 | |
| | American Midwest Conference Tournament Quarterfinals |
| | | 7:00PM | William Woods | @ | Harris-Stowe | 53-77 | |
| | American Midwest Conference Tournament Quarterfinals |
| | | 7:00PM | Illinois at Springfield | @ | Missouri Baptist | 53-74 | |
| | American Midwest Conference Tournament Quarterfinals |
| March |
| | 6 | 7:00PM | Missouri Baptist | @ | McKendree | 50-69 | |
| | American Midwest Conference Tournament Semifinals -- Rescheduled from March 4 |
| | | 7:00PM | Columbia | @ | Harris-Stowe | 63-56 | (OT) |
| | American Midwest Conference Tournament Semifinals -- Rescheduled from March 4 |
| | 8 | 2:00PM | Columbia | @ | McKendree | 66-78 | |
| | American Midwest Conference Tournament -- Championship |
| | 19 | 10:15AM | Harris-Stowe | vs. | Oklahoma City University | 73-64 | |
| | NAIA Tournament |
| | | 9:45PM | McKendree | vs. | Lewis-Clark State College | 49-69 | |
| | NAIA Division I Women's Basketball National Championship - First Round |
| | 21 | 10:45AM | Harris-Stowe | vs. | Carroll College | 53-62 | |
| | NAIA Tournamenet |