| August |
| % | 23 | 2:00PM | Missouri Valley College | @ | Hannibal-LaGrange | 0-0 | |
| | 27 | 5:00PM | Central Methodist College | @ | Hannibal-LaGrange | 0-1 | |
| % | | 7:00PM | Blackburn College | @ | University of Illinois at Springfield | 1-2 | |
| | 29 | 4:00PM | McKendree | @ | Judson College | 1-0 | |
| | at Judson University Tournament - Elgin, Ill. |
| | | 7:00PM | University of Illinois at Springfield | @ | Illinois Wesleyan | 2-1 | (OT) |
| | 30 | 12:00PM | Taylor University | vs. | McKendree | 1-4 | |
| | at Judson University Tournament - Elgin, Ill. |
| | | 3:00PM | Culver-Stockton College | @ | Harris-Stowe | 0-3 | |
| | | 3:00PM | Missouri Baptist | @ | Missouri Valley College | 0-1 | |
| | | 3:00PM | Hannibal-LaGrange | @ | Iowa Wesleyan College | 3-0 | |
| | | 5:00PM | Columbia | @ | Drury University | 0-1 | |
| | | 7:00PM | Central Methodist College | @ | William Woods | 3-3 | (2OT) |
| September |
| | 2 | 4:00PM | Ozark Christian College | @ | Williams Baptist | 1-5 | |
| | | 4:00PM | William Woods | @ | Culver-Stockton College | 3-0 | |
| | 3 | 7:00PM | Missouri Valley College | @ | McKendree | 0-3 | |
| | 4 | 5:00PM | Columbia | @ | Mid-Continent College | 1-1 | (2OT) |
| | | 7:00PM | Missouri Baptist | @ | Bethel College | 1-0 | |
| | 5 | | Hannibal-LaGrange | @ | Oklahoma City University | 1-0 | (2OT) |
| | John Brown University Tournament |
| | | 5:00PM | Williams Baptist | @ | Rhodes College | 2-6 | |
| | | 8:00PM | Harris-Stowe | @ | Freed-Hardeman | 2-1 | |
| | 6 | | Hannibal-LaGrange | @ | John Brown University | 3-0 | |
| | John Brown Tournament |
| | | 1:00PM | Columbia | @ | Berry College | 2-1 | |
| | | 4:00PM | Harris-Stowe | @ | Crichton College | 1-0 | |
| | | 5:00PM | Marian College | @ | McKendree | 0-1 | |
| | | 6:00PM | Missouri Baptist | @ | Kansas Wesleyan University | 3-2 | |
| | 7 | 2:30PM | University of Illinois at Springfield | @ | University of Missouri-Rolla | 3-1 | |
| | Missouri University of Science and Technology |
| | | 3:00PM | Iowa Wesleyan College | @ | William Woods | 0-2 | |
| | | 7:00PM | McKendree | @ | Westminster College | 4-1 | |
| | 9 | 4:00PM | Missouri Baptist | @ | Mid-Continent College | 0-2 | |
| | | 7:00PM | Harris-Stowe | @ | Central Methodist College | 1-2 | (OT) |
| | 10 | 7:00PM | Illinois Institute of Technology | @ | University of Illinois at Springfield | 2-1 | |
| | 11 | 5:00PM | Hannibal-LaGrange | @ | Millikin University | 3-0 | |
| | | 7:00PM | Missouri Baptist | @ | Westminster College | RAIN | |
| | | 7:00PM | Williams Baptist | @ | Freed-Hardeman | 1-2 | (OT) |
| | 12 | 6:00PM | Harris-Stowe | @ | Robert Morris College | 1-2 | |
| | | 7:00PM | Grand View College | @ | Columbia | 1-0 | |
| | 13 | 5:00PM | Harris-Stowe | @ | Illinois Institute of Technology | RAIN | |
| | | 7:00PM | Saint Joseph's College | @ | University of Illinois at Springfield | 1-2 | (2OT) |
| | | 7:00PM | William Woods | @ | Central Methodist College | 0-3 | |
| | 14 | 2:00PM | McKendree | @ | Benedictine College | 2-1 | |
| * | 16 | 2:00PM | Hannibal-LaGrange | @ | Harris-Stowe | 1-0 | |
| | | 5:00PM | Williams Baptist | @ | Central Baptist College | 4-3 | (OT) |
| * | | 7:00PM | Missouri Baptist | @ | William Woods | 4-2 | |
| | 17 | 7:00PM | Missouri-St. Louis | @ | University of Illinois at Springfield | 1-0 | (OT) |
| | | 7:00PM | Lindenwood University | @ | Columbia | 2-1 | |
| | 18 | 5:00PM | Williams Baptist | @ | Baptist Bible College | 11-2 | |
| | 19 | 1:00PM | Olivet Nazarene University | @ | McKendree | 3-3 | (2OT) |
| | | 5:00PM | Hannibal-LaGrange | @ | Lyon College | 1-0 | |
| * | 20 | 1:00PM | Hannibal-LaGrange | @ | Williams Baptist | 2-0 | |
| | | 2:00PM | Missouri Baptist | @ | Central Methodist College | 1-2 | |
| | | 3:00PM | McKendree | @ | Culver-Stockton College | 3-0 | |
| | | 3:00PM | Harris-Stowe | @ | John Brown University | 1-4 | |
| | | 7:00PM | Saint Xavier University | @ | University of Illinois at Springfield | 2-4 | |
| | | 7:00PM | Park | @ | Columbia | 3-2 | |
| | | 7:00PM | William Woods | @ | Benedictine College | 0-1 | |
| | 21 | 3:00PM | Harris-Stowe | @ | Central Baptist College | 0-1 | |
| * | 23 | 4:00PM | McKendree | @ | Harris-Stowe | 4-0 | |
| * | | 7:00PM | Columbia | @ | University of Illinois at Springfield | 1-2 | |
| * | 26 | 3:00PM | Harris-Stowe | @ | Missouri Baptist | 2-1 | (2OT) |
| * | | 3:00PM | Columbia | @ | Williams Baptist | 4-1 | |
| | | 7:00PM | Hannibal-LaGrange | @ | Bethel College | 1-0 | |
| | 27 | 2:30PM | Hannibal-LaGrange | @ | McPherson College | 6-0 | |
| | Marks 10th Consecutive Trojan Shutout |
| | | 4:00PM | Missouri Baptist | @ | Lambuth University | 0-1 | |
| * | | 5:00PM | William Woods | @ | McKendree | 0-8 | |
| | | 6:00PM | University of Illinois at Springfield | @ | Southern Indiana | 0-2 | |
| | 28 | 4:00PM | Harris-Stowe | @ | Missouri Valley College | 0-3 | |
| * | 29 | 12:00PM | Williams Baptist | @ | Missouri Baptist | 1-2 | |
| | | 5:00PM | Tabor College | @ | William Woods | 1-2 | |
| | 30 | 7:00PM | Westminster College | @ | Columbia | 1-5 | |
| October |
| * | 1 | 7:00PM | University of Illinois at Springfield | @ | McKendree | 1-3 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | Missouri Baptist | 2-0 | |
| | 2 | 4:00PM | Westminster College | @ | Harris-Stowe | 3-1 | |
| * | | 7:00PM | Columbia | @ | William Woods | 3-1 | |
| | 4 | 1:00PM | Missouri Baptist | @ | Maryville University-St. Louis | 2-1 | (OT) |
| * | | 3:00PM | McKendree | @ | Hannibal-LaGrange | 0-2 | |
| * | | 3:00PM | Harris-Stowe | @ | Columbia | 0-3 | |
| | | 3:00PM | William Woods | @ | Mount Mercy College | 2-3 | (OT) |
| * | | 7:00PM | Williams Baptist | @ | University of Illinois at Springfield | 0-3 | |
| | 6 | 3:00PM | Crichton College | @ | Williams Baptist | 2-3 | |
| | | 7:00PM | Avila College | @ | William Woods | 1-3 | |
| | | 8:00PM | Missouri Baptist | @ | Lindenwood University | 1-2 | |
| * | 8 | 4:00PM | University of Illinois at Springfield | @ | Hannibal-LaGrange | 3-2 | |
| * | | 5:00PM | Harris-Stowe | @ | William Woods | 1-4 | |
| | 10 | 7:00PM | McKendree | @ | Southern Illinois-Edwardsville | 0-2 | |
| | 11 | 1:00PM | Missouri Baptist | @ | York College | 1-0 | |
| * | | 2:00PM | University of Illinois at Springfield | @ | William Woods | 1-2 | (2OT) |
| | | 3:00PM | Rust College | @ | Williams Baptist | 3-5 | |
| * | 14 | 2:00PM | University of Illinois at Springfield | @ | Harris-Stowe | 3-0 | |
| * | | 4:00PM | William Woods | @ | Williams Baptist | 3-1 | |
| * | | 7:00PM | Columbia | @ | McKendree | 0-2 | |
| * | 17 | 4:00PM | Williams Baptist | @ | Harris-Stowe | 0-2 | |
| * | | 7:00PM | Hannibal-LaGrange | @ | Columbia | 0-0 | (2OT) |
| * | 18 | 7:00PM | Missouri Baptist | @ | University of Illinois at Springfield | 0-1 | (2OT) |
| | | 7:00PM | William Woods | @ | Bellevue University | 0-1 | (OT) |
| | 19 | 1:00PM | William Woods | @ | Midland Lutheran College | 5-1 | |
| | 20 | 3:00PM | Baptist Bible College | @ | Williams Baptist | 1-12 | |
| * | 21 | 7:00PM | Missouri Baptist | @ | Columbia | 0-1 | |
| | 22 | 3:00PM | Truman State University | @ | Hannibal-LaGrange | 2-0 | |
| | | 7:00PM | North Park University | @ | University of Illinois at Springfield | 2-3 | (2OT) |
| * | 23 | 6:00PM | McKendree | @ | Missouri Baptist | 1-0 | (2OT) |
| | Will be played at McKendree University |
| * | 25 | 1:00PM | William Woods | @ | Hannibal-LaGrange | 0-2 | |
| | | 2:00PM | Columbia | @ | John Brown University | 3-2 | |
| | | 7:00PM | Trinity International University | @ | University of Illinois at Springfield | 2-2 | (2OT) |
| | | 7:00PM | Williams Baptist | @ | Hendrix College | 2-3 | |
| | 26 | 1:00PM | Columbia | @ | Rodgers State | 1-1 | (2OT) |
| | 28 | 3:00PM | Lyon College | @ | Williams Baptist | 3-2 | (OT) |
| | | 3:00PM | Hannibal-LaGrange | @ | Culver-Stockton College | 3-0 | |
| | | 7:00PM | Lindenwood University | @ | McKendree | 4-2 | |
| | 29 | 4:00PM | Harris-Stowe | @ | Southern Indiana | 0-1 | |
| | | 5:00PM | Missouri Valley College | @ | William Woods | 1-2 | |
| | | 7:00PM | Baker University | @ | Columbia | 1-2 | (2OT) |
| * | 30 | 5:30PM | Williams Baptist | @ | McKendree | 0-4 | |
| | McKendree clinches second consecutive AMC regular season championship |
| | | 7:00PM | Saint Ambrose University | @ | University of Illinois at Springfield | 1-1 | (2OT) |
| November |
| | 2 | 1:00PM | Columbia | @ | Truman State University | 0-1 | |
| | 4 | 7:30PM | Drury University | @ | McKendree | 0-0 | (2OT) |
| | 8 | 1:00PM | William Woods | @ | Columbia | 0-1 | |
| | AMC Quarterfinals |
| | | 1:00PM | Harris-Stowe | @ | University of Illinois at Springfield | 2-2 | (2OT) |
| | 2008 AMC Tournament - First Round - HSSU Advances on Penalty Kicks, 4-2 |
| | 11 | 1:00PM | Harris-Stowe | @ | Hannibal-LaGrange | 0-4 | |
| | 2008 AMC Tournament Semifinals |
| | | 6:00PM | Columbia | @ | McKendree | 0-2 | |
| | AMC Tournament Semifinals |
| | 14 | 5:00PM | Hannibal-LaGrange | @ | McKendree | 5-1 | |
| | AMC Tournament Championship |
| | 22 | 5:00PM | Hannibal-LaGrange | @ | Hastings College | 1-1 | (2OT) |
| | Hastings Defeats Hannibal-LaGrange in PK shootout 4-2 |
