| | Day | Time | | Opponent | Score | |
| August |
| | 28 | 7:00PM | Lindenwood University | vs. | Illinois at Springfield | L-0-3 |  |
| | 31 | | National American University | vs. | Missouri Baptist | L-2-3 | |
| | Best Western Classic |
| | | | Bryan College | vs. | Missouri Baptist | W-3-2 | |
| | Best Western Classic |
| | | 11:00AM | Southern Nazarene University | vs. | Columbia | W-3-0 | |
| | Best Western Volleyball Classic hosted by Columbia College |
| | | 1:00PM | William Woods | vs. | Montana Tech of the Univ of Montana | W-3-0 | |
| | Concordia Tournament |
| | | 4:00PM | Illinois at Springfield | vs. | Dordt College | W-3-1 | |
| | Cornerstone Classic |
| | | 5:00PM | William Woods | vs. | Carroll College | W-3-1 | |
| | Concordia Tournament |
| | | 6:00PM | Illinois at Springfield | vs. | Illinois Institute of Technology | W-3-0 | |
| | Cornerstone Classic |
| | | 6:00PM | Harris-Stowe | vs. | Blackburn College | L-1-3 | |
| | | 7:00PM | Lindenwood University | vs. | Columbia | L-1-3 | |
| | Best Western Volleyball Classic hosted by Columbia College |
| | | 8:00PM | Harris-Stowe | vs. | Eureka College | W-3-0 | |
| September |
| | 1 | | Lindenwood University | vs. | Missouri Baptist | L-1-3 | |
| | Best Western Classic |
| | | 9:00AM | National American University | vs. | Columbia | L-2-3 | |
| | Best Western Volleyball Classic hosted by Columbia College |
| | | 11:00AM | Missouri Baptist | vs. | Columbia | W-3-0 | |
| | Best Western Volleyball Classic hosted by Columbia College |
| | | 12:00PM | Illinois at Springfield | vs. | Davenport University | L-1-3 | |
| | Cornerstone Classic |
| | | 2:00PM | Illinois at Springfield | vs. | Cornerstone University | W-3-0 | |
| | Cornerstone Classic |
| | | 2:00PM | Harris-Stowe | vs. | Iowa Wesleyan College | W-3-0 | |
| | | 3:00PM | Robert Morris College | vs. | McKendree | W-3-0 | |
| | Tri-Match |
| | | 4:00PM | Harris-Stowe | vs. | Knox College | L-0-3 | |
| | | 5:00PM | William Woods | vs. | Christian Heritage College | W-3-0 | |
| | | 7:00PM | Spalding University | vs. | McKendree | W-3-2 | |
| | Tri-Match |
| | | 9:00PM | William Woods | vs. | Western Baptist College | W-3-1 | |
| | 4 | 7:00PM | Quincy University | vs. | Illinois at Springfield | L-1-3 | |
| * | | 9:00PM | Harris-Stowe | vs. | Columbia | W-3-0 | |
| | 5 | 9:00PM | Webster University | vs. | McKendree | W-3-2 | |
| | 7 | | Columbia | vs. | Michigan Dearborn | L-1-3 | |
| | Graceland Pizza Shack Invitational |
| | | | Columbia | vs. | Westminster College of Salt Lake City | W-3-0 | |
| | Graceland Pizza Shack Invitational |
| | | | Olivet Nazarene University | vs. | Missouri Baptist | W-3-1 | |
| | Graceland Tournament |
| | | | Dickinson State University | vs. | Missouri Baptist | L-1-3 | |
| | Graceland Tournament |
| | | 1:00PM | Harris-Stowe | vs. | Park University | W-3-0 | |
| | | 4:00PM | McKendree | vs. | Cardinal Stritch University | L-0-3 | |
| | Saint Xavier University Tournament |
| | | 6:00PM | Harris-Stowe | vs. | College of the Ozarks | W-3-0 | |
| | Mazzio's KCAC/MCAC Challenge |
| | | 8:00PM | University of Saint Francis | vs. | McKendree | W-3-0 | |
| | Saint Xavier University Cougar Invitational |
| | 8 | | Columbia | vs. | Indiana Wesleyan University | L-1-3 | |
| | Graceland Pizza Shack Invitational |
| | | | Columbia | vs. | Lindenwood University | L-0-3 | |
| | Graceland Pizza Shack Invitational |
| | | | Lindenwood University | vs. | Missouri Baptist | L-1-3 | |
| | Graceland Tournament |
| | | | Indiana Wesleyan University | vs. | Missouri Baptist | L-1-3 | |
| | Graceland Tournament |
| | | 10:00AM | McKendree | vs. | Aquinas College | L-1-3 | |
| | Saint Xavier University Tournament |
| | | 1:00PM | Harris-Stowe | vs. | Oklahoma Wesleyan University | W-3-0 | |
| | | 2:00PM | Westminster College | vs. | William Woods | W-3-0 | |
| | | 2:00PM | McKendree | vs. | Saint Xavier University | L-1-3 | |
| | Saint Xavier University Invitational |
| | | 3:00PM | Oklahoma Wesleyan University | vs. | Harris-Stowe | L-0-3 | |
| | | 3:00PM | Harris-Stowe | vs. | Peru State College | W-3-0 | |
| | | 6:00PM | Central Methodist College | vs. | William Woods | L-0-3 | |
| * | 11 | 7:00PM | McKendree | vs. | Williams Baptist | L-1-3 | |
| * | | 7:00PM | Harris-Stowe | vs. | William Woods | W-3-0 | |
| | Game one of DH |
| * | | 7:00PM | Missouri Baptist | vs. | Columbia | W-3-0 | |
| | | 8:00PM | Illinois at Springfield | vs. | Webster University | L-1-3 | |
| * | | 9:00PM | Harris-Stowe | vs. | William Woods | W-3-0 | |
| | Game two of DH |
| * | 13 | 9:00PM | Hannibal-LaGrange | vs. | McKendree | W-3-0 | |
| | McKendree is off to its first 9-0 start in program history |
| | 14 | | Hannibal-LaGrange | vs. | Union College | W-3-1 | |
| | Union College Tournament - Barbourville, KY |
| | | 5:00PM | Illinois at Springfield | vs. | Midland Lutheran College | L-1-3 | |
| | Taylor Trojan Challenge |
| | | 7:00PM | Illinois at Springfield | vs. | Taylor University | W-3-1 | |
| | Taylor University Trojan Challenge Sept. 14-15 |
| * | | 7:00PM | William Woods | vs. | Missouri Baptist | W-3-0 | |
| * | | 7:00PM | Columbia | vs. | Harris-Stowe | L-0-3 | |
| | 15 | | Illinois at Springfield | vs. | Houghton College | W-3-0 | |
| | Taylor Trojan Challenge |
| * | | 12:00PM | Columbia | vs. | Williams Baptist | L-1-3 | |
| * | | 2:00PM | Columbia | vs. | Williams Baptist | L-1-3 | |
| | | 2:00PM | Illinois at Springfield | vs. | Cedarville University | W-3-1 | |
| | Taylor Challenge Tournament |
| * | 18 | 3:00PM | Williams Baptist | vs. | Illinois at Springfield | W-3-2 | |
| * | | 7:00PM | Hannibal-LaGrange | vs. | Illinois at Springfield | W-3-0 | |
| * | | 7:00PM | William Woods | vs. | Columbia | W-3-0 | |
| | | 7:00PM | Stephens College | vs. | Harris-Stowe | W-3-1 | |
| * | 19 | 7:00PM | Harris-Stowe | vs. | Missouri Baptist | W-3-0 | |
| * | 20 | 7:00PM | McKendree | vs. | Illinois at Springfield | L-0-3 | |
| * | 21 | 4:00PM | William Woods | vs. | Williams Baptist | W-3-2 | |
| | | 6:00PM | Bethel College | vs. | William Woods | W-3-0 | |
| | | 6:00PM | Missouri Baptist | vs. | Trinity International University | L-0-3 | |
| | Trinity Christian Tournament |
| | | 7:00PM | McKendree | vs. | Ohio Dominican College | L-0-3 | |
| | Campbellsville University Tournament |
| | | 8:00PM | Missouri Baptist | vs. | Trinity Christian College | L-0-3 | |
| | Trinity Christian Tournament |
| | 22 | 9:00AM | McKendree | vs. | Campbellsville University | W-3-0 | |
| | Campbellsville University Tournament |
| | | 10:00AM | Missouri Baptist | vs. | Bethel College | L-1-3 | |
| | Trinity Christian Tournament |
| | | 12:00PM | Missouri Baptist | vs. | Graceland University | L-0-3 | |
| | Trinity Christian Tournament |
| | | 1:00PM | McKendree | vs. | Indiana University Southeast | L-1-3 | |
| | Campbellsville Universitiy Tournament |
| | | 5:00PM | Truman State University | vs. | Columbia | L-0-3 | |
| | Truman State is ranked No. 8 in NCAA Division II |
| | 24 | 7:00PM | St. Louis College of Pharmacy | vs. | Harris-Stowe | W-3-2 | |
| | 25 | 7:00PM | Illinois at Springfield | vs. | Greenville College | L-1-3 | |
| * | | 9:00PM | McKendree | vs. | Harris-Stowe | L-0-3 | |
| | 26 | 7:00PM | Saint Louis College of Pharmacy | vs. | Illinois at Springfield | W-3-0 | |
| * | 27 | 7:00PM | Columbia | vs. | McKendree | L-1-3 | |
| * | | 7:00PM | Missouri Baptist | vs. | Hannibal-LaGrange | L-0-3 | |
| | | 9:00PM | Central Methodist College | vs. | Stephens College | | |
| * | 28 | 7:00PM | William Woods | vs. | McKendree | W-3-0 | |
| * | | 7:00PM | Missouri Baptist | vs. | Illinois at Springfield | L-2-3 | |
| * | | 7:00PM | Harris-Stowe | vs. | Hannibal-LaGrange | W-3-0 | |
| * | 29 | 2:00PM | Harris-Stowe | vs. | Illinois at Springfield | W-3-0 | |
| | | 3:30PM | McKendree | vs. | Greenville College | L-1-3 | |
| October |
| * | 2 | 7:00PM | Illinois at Springfield | vs. | William Woods | L-1-3 | |
| * | 3 | 7:00PM | Illinois at Springfield | vs. | Columbia | W-3-0 | |
| * | | 9:00PM | McKendree | vs. | Missouri Baptist | W-3-1 | |
| | Dig for the Cure night |
| | 5 | | Illinois at Springfield | vs. | Lindenwood University | W-3-0 | |
| | Lindenwood University Tourney |
| | | | Evangel University | vs. | Missouri Baptist | W-3-1 | |
| | Lindenwood University Invitational |
| | | | Benedictine College | vs. | Missouri Baptist | W-3-1 | |
| | Lindenwood Tournament |
| | | | Illinois at Springfield | vs. | Baker University | L-1-3 | |
| | @ Lindenwood Tournament |
| | | 3:00PM | McKendree | vs. | Baker University | W-3-0 | |
| | Lindenwood University Tournament |
| | | 3:00PM | Culver-Stockton College | vs. | Harris-Stowe | L-0-3 | |
| * | | 7:00PM | Hannibal-LaGrange | vs. | William Woods | W-3-1 | |
| | | 7:00PM | Columbia | vs. | Black Hills State University | W-3-2 | |
| | | 7:00PM | McKendree | vs. | William Jewell College | W-3-0 | |
| | Lindenwood University Tournament |
| | 6 | | Illinois at Springfield | vs. | Evangel University | W-3-0 | |
| | Lindenwood University Tourney |
| | | | Baker University | vs. | Missouri Baptist | L-0-3 | |
| | Lindenwood Tournament |
| | | | Culver-Stockton College | vs. | Missouri Baptist | W-3-0 | |
| | Lindenwood Tournament |
| | | | Illinois at Springfield | vs. | Culver-Stockton College | L-0-3 | |
| | @Lindenwood tournament |
| | | 11:30AM | McKendree | vs. | Benedictine College | L-1-3 | |
| | Lindenwood University Tournament |
| | | 2:00PM | Columbia | vs. | National American University | W-3-1 | |
| | | 2:00PM | William Jewell College | vs. | Harris-Stowe | L-0-3 | |
| | | 3:30PM | McKendree | vs. | Evangel University | W-3-2 | |
| | Lindenwood University Tournament |
| | | 4:00PM | Lindenwood University | vs. | Harris-Stowe | L-0-3 | |
| | | 6:00PM | Columbia | vs. | Dickinson State University | L-1-3 | |
| | at National American University (S.D.) |
| * | 9 | 7:00PM | Missouri Baptist | vs. | William Woods | L-0-3 | |
| * | | 9:00PM | McKendree | vs. | Hannibal-LaGrange | L-1-3 | |
| | 10 | 7:00PM | Illinois College | vs. | Illinois at Springfield | W-3-0 | |
| * | 11 | 7:00PM | Columbia | vs. | Missouri Baptist | L-0-3 | |
| | | 9:00PM | Stephens College | vs. | Central Methodist College | | |
| | 12 | | Stephens College | vs. | Harris-Stowe | L-1-3 | |
| | | | Berea College | vs. | Harris-Stowe | W-3-1 | |
| | | | Saint Louis College of Pharmacy | vs. | Harris-Stowe | W-3-1 | |
| * | | 3:00PM | Illinois at Springfield | vs. | McKendree | L-2-3 | |
| | | 5:00PM | Trevecca Nazarene University | vs. | Illinois at Springfield | L-0-3 | |
| | McKendree Tri-match - Lebanon, Ill. |
| | | 9:00PM | Trevecca Nazarene University | vs. | McKendree | L-1-3 | |
| | 13 | | Midway College | vs. | Harris-Stowe | W-3-0 | |
| | | | Stephens College | vs. | Harris-Stowe | L-0-3 | |
| | | 11:00AM | Trevecca Nazarene University | vs. | McKendree | L-1-3 | |
| | McKendree Tri-match - Lebanon, Ill. |
| * | | 12:00PM | Illinois at Springfield | vs. | Williams Baptist | W-3-0 | |
| | | 3:00PM | Lindenwood University | vs. | McKendree | L-1-3 | |
| * | 15 | 5:00PM | Missouri Baptist | vs. | Williams Baptist | W-3-2 | |
| * | | 7:00PM | Hannibal-LaGrange | vs. | Columbia | W-3-0 | |
| * | | 7:00PM | Missouri Baptist | vs. | Williams Baptist | L-1-3 | |
| * | 16 | 3:00PM | Illinois at Springfield | vs. | Hannibal-LaGrange | L-0-3 | |
| | | 5:00PM | Illinois at Springfield | vs. | Culver-Stockton College | L-2-3 | |
| | | 7:00PM | Culver-Stockton College | vs. | Hannibal-LaGrange | L-2-3 | |
| * | | 7:00PM | Columbia | vs. | William Woods | L-1-3 | |
| * | 17 | 7:00PM | Missouri Baptist | vs. | Harris-Stowe | L-0-3 | |
| | 19 | | Missouri Baptist | vs. | Oakland City University | L-0-3 | |
| | | 2:00PM | Illinois at Springfield | vs. | Saint Xavier University | W-3-0 | |
| | St. Francis Big Guns Tourney |
| | | 4:00PM | Illinois at Springfield | vs. | Marian College | L-0-3 | |
| | St. Francis Big Guns Tourney |
| * | | 6:00PM | Missouri Baptist | vs. | McKendree | L-0-3 | |
| * | | 7:00PM | William Woods | vs. | Hannibal-LaGrange | W-3-2 | |
| | | 10:00PM | Central Methodist College | vs. | McKendree | L-2-3 | |
| | 20 | | Missouri Baptist | vs. | Lindenwood University | W-3-0 | |
| * | | 1:00PM | Harris-Stowe | vs. | McKendree | W-3-0 | |
| | | 1:00PM | Harris-Stowe | vs. | Central Methodist College | W-3-0 | |
| | | 2:00PM | Illinois at Springfield | vs. | Trinity Christian College | W-3-0 | |
| | St. Francis Big Guns Tourney |
| | | 2:00PM | Illinois at Springfield | vs. | University of Saint Francis | L-2-3 | |
| | St. Francis Big Guns Tourney |
| | | 3:00PM | William Woods | vs. | Iowa Wesleyan College | L-1-3 | |
| | | 5:00PM | Missouri Valley College | vs. | William Woods | W-3-0 | |
| | Iowa Wesleyan University Invitational - Mt. Pleasant, IA |
| | | 5:00PM | Oakland City University | vs. | McKendree | W-3-0 | |
| | | 7:00PM | William Jewell College | vs. | Missouri Baptist | W-3-0 | |
| * | 22 | 5:00PM | Williams Baptist | vs. | Harris-Stowe | L-0-3 | |
| * | | 7:00PM | Columbia | vs. | Hannibal-LaGrange | L-0-3 | |
| * | | 7:00PM | Williams Baptist | vs. | Harris-Stowe | L-0-3 | |
| * | 23 | 5:00PM | Williams Baptist | vs. | McKendree | W-3-1 | |
| * | | 7:00PM | William Woods | vs. | Illinois at Springfield | W-3-1 | |
| * | 24 | 7:00PM | Illinois at Springfield | vs. | Harris-Stowe | L-0-3 | |
| * | | 7:00PM | McKendree | vs. | Columbia | W-3-1 | |
| | | 7:00PM | Missouri Baptist | vs. | Missouri-St. Louis | L-0-3 | |
| | 26 | 3:00PM | William Woods | vs. | Webster University | W-3-0 | |
| | Washington University Tournament |
| | | 3:00PM | Campbellsville University | vs. | Columbia | W-3-1 | |
| | | 5:15PM | William Woods | vs. | Peru State College | W-3-2 | |
| | Washington University Tournament |
| | | 7:00PM | Grace College | vs. | Illinois at Springfield | W-3-0 | |
| | UIS Tourney |
| | | 7:00PM | University of Saint Francis | vs. | Columbia | W-3-0 | |
| | Bone Yard Brawl Tournament |
| | 27 | 10:00AM | William Woods | vs. | Principia College | W-3-2 | |
| | Washington University Tournament |
| | | 12:15PM | William Woods | vs. | Adrian College | W-3-2 | |
| | Washington University Tournament |
| | | 1:00PM | Park University | vs. | Illinois at Springfield | W-3-0 | |
| | UIS Tourney |
| | | 1:00PM | Freed-Hardeman | vs. | Columbia | W-3-0 | |
| | Georgetown University Tournament |
| | | 5:00PM | Purdue University-North Central | vs. | Illinois at Springfield | W-3-0 | |
| | UIS Tourney |
| | | 5:00PM | Columbia | vs. | Georgetown College | L-0-3 | |
| * | 30 | 7:00PM | Columbia | vs. | Illinois at Springfield | L-1-3 | |
| * | | 7:00PM | William Woods | vs. | McKendree | W-3-0 | |
| * | | 7:00PM | Hannibal-LaGrange | vs. | Missouri Baptist | W-3-0 | |
| * | 31 | 7:00PM | Illinois at Springfield | vs. | Missouri Baptist | W-3-0 | |
| November |
| * | 2 | 6:00PM | Williams Baptist | vs. | William Woods | W-3-2 | |
| | 3 | 10:00AM | McKendree | vs. | Michigan Dearborn | W-3-1 | |
| | | 12:00PM | McKendree | vs. | Huntington College | W-3-2 | |
| | | 2:00PM | McKendree | vs. | Lindsey Wilson | W-3-1 | |
| | 6 | 7:00PM | William Woods | vs. | McKendree | W-3-0 | |
| | AMC Volleyball Tournament -- Quarterfinals |
| | | 7:00PM | Harris-Stowe | vs. | Columbia | W-3-0 | |
| | AMC Volleyball Tournament -- Quarterfinals |
| | | 7:00PM | Hannibal-LaGrange | vs. | Missouri Baptist | W-3-0 | |
| | AMC Volleyball Tournament -- Quarterfinals |
| | | 7:00PM | Williams Baptist | vs. | Illinois at Springfield | W-3-0 | |
| | AMC Volleyball Tournament -- Quarterfinals. UIS advances to face Columbia College at 7 p.m. on Thursday. |
| | 8 | | Illinois at Springfield | vs. | Columbia | W-3-0 | |
| | AMC quarterfinals |
| | | 7:00PM | McKendree | vs. | Missouri Baptist | W-3-0 | |
| | AMC Volleyball Tournament--Semi-Finals |
| | 10 | 12:00PM | Missouri Baptist | vs. | Columbia | W-3-0 | |
| | AMC Tournament Championship game |
| | 13 | 7:00PM | Missouri Baptist | vs. | Evangel University | W-3-2 | |
| | First-Round Region V Tournament played at Parkway South High School |
| | | 7:00PM | Central Methodist College | vs. | Columbia | W-3-0 | |
| | | 7:00PM | Illinois at Springfield | vs. | Lindenwood University | W-3-1 | |
| | Region V Tournament First Round |
| | 16 | 7:00PM | William Jewell College | vs. | Columbia | W-3-0 | |
| | Region V semifinals |
| | 17 | 12:00PM | Lindenwood University | vs. | Columbia | L-2-3 | |
| | Region V Championship |
