| | Day | Time | | Opponent | Score | |
| November |
| | 3 | 7:00PM | vs. | Park University | L-61-70 | |
| | 7 | 6:30PM | @ | Georgetown College | L-63-76 | |
| | 10 | 7:00PM | vs. | Saint Xavier University | L-77-84 | |
| | 12 | 7:00PM | vs. | Lincoln University | W-64-54 | |
| | 14 | 7:00PM | vs. | Lindenwood University | W-62-54 | |
| | 16 | 7:00PM | @ | Culver-Stockton College | L-44-60 | |
| | 19 | 7:00PM | vs. | Missouri-St. Louis | W-70-57 | |
| | 23 | 7:30PM | @ | Lindsey Wilson | W-85-83 (2OT) | |
| | 24 | 1:00PM | @ | Campbellsville University | W-70-69 (OT) | |
| | 27 | 5:30PM | @ | Olivet Nazarene University | L-86-97 | |
| December |
| | 5 | 7:00PM | @ | Millikin University | L-60-67 | |
| | 7 | 7:00PM | vs. | Washington University | W-76-49 | |
| | Bearcats defeat NCAA Division III pre-season No. 1 squad |
| January |
| | 3 | 7:00PM | @ | Brescia University | L-54-66 | |
| | 5 | 2:00PM | @ | Park University | W-66-57 | |
| * | 8 | 7:00PM | vs. | William Woods | W-79-70 | |
| * | 12 | 2:00PM | @ | Williams Baptist | W-59-45 | |
| * | 15 | 7:00PM | vs. | Illinois at Springfield | W-71-58 | |
| * | 19 | 2:00PM | vs. | Missouri Baptist | W-73-66 | |
| * | 22 | 7:00PM | @ | Harris-Stowe | L-63-67 | |
| | 24 | 7:00PM | vs. | Brescia University | W-72-50 | |
| * | 26 | 2:00PM | vs. | Columbia | W-78-58 | |
| * | 29 | 7:00PM | @ | Hannibal-LaGrange | W-85-61 | |
| February |
| * | 2 | 2:00PM | @ | William Woods | W-86-70 | |
| * | 5 | 7:00PM | vs. | Williams Baptist | W-68-51 | |
| * | 9 | 2:00PM | @ | Illinois at Springfield | W-78-67 | |
| * | 12 | 7:00PM | @ | Missouri Baptist | W-78-71 | |
| | McKendree's Heather Elders surpasses 1,000-point mark for her career in the win |
| * | 16 | 2:00PM | vs. | Harris-Stowe | W-72-50 | |
| | McKendree holds Harris-Stowe to 32.3% shooting for the game |
| * | 19 | 7:00PM | @ | Columbia | W-67-61 | |
| * | 23 | 2:00PM | vs. | Hannibal-LaGrange | W-72-55 | |
| | 29 | 7:00PM | vs. | Hannibal-LaGrange | W-84-37 | |
| | American Midwest Conference Tournament Quarterfinals |
| March |
| | 6 | 7:00PM | vs. | Missouri Baptist | W-69-50 | |
| | American Midwest Conference Tournament Semifinals -- Rescheduled from March 4 |
| | 8 | 2:00PM | vs. | Columbia | W-78-66 | |
| | American Midwest Conference Tournament -- Championship |
| | 19 | 9:45PM | vs. | Lewis-Clark State College | L-49-69 | |
| | NAIA Division I Women's Basketball National Championship - First Round |
