| | Day | Time | | Opponent | Score | |
| February |
| | 27 | 2:00PM | @ | William Jewell College | W-12-1 (6) | |
| | | Game 2 | @ | William Jewell College | W-6-1 | |
| | 29 | | @ | Iowa Wesleyan College | W-7-0 | |
| March |
| | 1 | | @ | Rockhurst University | W-3-0 | |
| | | 6:00PM | vs. | Hillsdale Free Will Baptist College | W-14-1 | |
| | 9 | 2:00PM | @ | Kansas Wesleyan University | W-7-3 | |
| | | 4:00PM | @ | Rodgers State | L-0-1 | |
| | 14 | | vs. | Thomas University | L-7-9 | |
| | | 2:00PM | @ | Spring Hill College | W-5-1 | |
| | 15 | 11:00AM | vs. | Shorter College | L-0-5 | |
| | | 5:00PM | vs. | Oklahoma Baptist University | W-11-1 | |
| | 16 | 9:00AM | vs. | Southern Nazarene University | W-2-1 (8) | |
| | | 11:00AM | vs. | Thomas University | W-3-2 | |
| | | 1:00PM | vs. | Faulkner University | W-4-1 | |
| | Columbia wins Silver Bracket Championship at Gulf Coast Invitational |
| | 19 | 2:00PM | @ | Culver-Stockton College | W-5-3 | |
| | | Game 2 | @ | Culver-Stockton College | W-3-2 | |
| * | 21 | 2:00PM | vs. | Harris-Stowe | W-4-0 | |
| * | | Game 2 | vs. | Harris-Stowe | W-9-1 | |
| | 25 | 1:30PM | @ | California Baptist University | L-0-8 (6) | |
| | | Game 2 | @ | California Baptist University | L-1-5 (7) | |
| | 26 | 2:00PM | @ | Vanguard University | L-0-3 | |
| | | Game 2 | @ | Vanguard University | W-1-0 (8) | |
| | 27 | 4:00PM | @ | Azusa Pacific University | W-4-2 | |
| | | Game 2 | @ | Azusa Pacific University | W-2-1 | |
| April |
| * | 1 | 2:00PM | vs. | University of Illinois at Springfield | L-0-1 | |
| * | | Game 2 | vs. | University of Illinois at Springfield | W-6-0 | |
| * | 4 | 2:00PM | vs. | McKendree | W-2-0 | |
| * | | Game 2 | vs. | McKendree | W-6-2 | |
| * | 11 | 2:00PM | vs. | William Woods | W-4-1 | |
| * | | Game 2 | vs. | William Woods | W-6-2 | |
| | 12 | 4:00PM | vs. | Saint Xavier University | RAIN | |
| | | Game 2 | vs. | Saint Xavier University | RAIN | |
| * | 15 | 2:00PM | @ | Hannibal-LaGrange | W-16-1 (5) | |
| * | | Game 2 | @ | Hannibal-LaGrange | W-6-0 | |
| * | 16 | 2:00PM | @ | Missouri Baptist | W-13-4 (5) | |
| * | | Game 2 | @ | Missouri Baptist | L-5-6 | |
| | 18 | 4:00PM | vs. | Peru State College | W-4-1 | |
| | | 8:00PM | vs. | Southern Nazarene University | W-4-0 | |
| | 19 | 10:00AM | vs. | East Central University | W-4-1 | |
| | | 4:00PM | vs. | University of Houston-Victoria | L-2-3 (10) | |
| * | 21 | 2:00PM | @ | Williams Baptist | W-6-1 | |
| * | | Game 2 | @ | Williams Baptist | W-5-4 | |
| | 24 | 12:00PM | vs. | Hannibal-LaGrange | W-6-0 | |
| | Katie McMahon throws a near perfect game for Columbia, giving up just one walk |
| | | 6:00PM | vs. | Williams Baptist | W-1-0 | |
| | 25 | 2:00PM | vs. | William Woods | W-10-6 | |
| | Columbia advances to the AMC Championship Game |
| | 26 | 1:00PM | vs. | William Woods | W-9-0 (5) | |
| | AMC Tournament Championship Game |
| May |
| | 6 | 12:00PM | vs. | William Jewell College | W-11-10 | |
| | Region V Tournament |
| | | 10:00PM | vs. | William Woods | W-2-0 | |
| | Region V Tournament |
| | 8 | 2:00PM | vs. | Central Methodist College | L-1-4 | |
| | | 6:00PM | vs. | William Jewell College | W-9-7 (11) | |
| | 9 | 12:00PM | vs. | Central Methodist College | W-3-1 | |
| | | 2:00PM | vs. | Central Methodist College | W-7-6 (8) | |
