| | Day | Time | | Opponent | Score | |
| February |
| | 29 | 12:00PM | vs. | Coe College | L-2-5 | |
| | Games played at Maryville University in St. Louis |
| | | Game 2 | vs. | Coe College | W-3-2 | |
| | Game played at Maryville University in St. Louis |
| March |
| | 1 | 12:00PM | vs. | Olivet Nazarene University | RAIN | |
| | | Game 2 | vs. | Olivet Nazarene University | RAIN | |
| | 9 | 11:30AM | vs. | Iowa Wesleyan College | W-9-1 (5) | |
| | Tucson Invitational |
| | 10 | 6:00PM | vs. | Jamestown College | W-2-0 | |
| | Tucson Invitational |
| | 11 | 8:30AM | vs. | Hendrix College | W-6-3 | |
| | Tucson Invitational |
| | | 5:30PM | vs. | Judson College | L-2-3 | |
| | Tucson Invitational |
| | 13 | 8:30AM | vs. | Purdue University-North Central | L-2-6 | |
| | Tucson Invitational |
| | | 10:30AM | vs. | Robert Morris College | L-4-5 | |
| | Tucson Invitational |
| | 14 | 3:00PM | vs. | Missouri Valley College | W-6-3 | |
| | Tucson Invitational |
| | | 5:00PM | vs. | Cornerstone University | W-11-2 (5) | |
| | Tucson Invitational |
| * | 20 | 2:00PM | vs. | Hannibal-LaGrange | W-7-1 | |
| * | | Game 2 | @ | Hannibal-LaGrange | W-7-1 | |
| * | 25 | 2:00PM | vs. | Williams Baptist | W-8-0 | |
| * | | Game 2 | vs. | Williams Baptist | W-4-1 | |
| * | 27 | 2:00PM | @ | William Woods | RAIN | |
| * | | Game 2 | @ | William Woods | RAIN | |
| * | 28 | 2:00PM | @ | William Woods | L-7-8 (9) | |
| * | | Game 2 | @ | William Woods | L-4-16 | |
| | 29 | 11:00AM | vs. | MidAmerica Nazarene University | W-13-3 (5) | |
| | Avila Tournament - March 29-30 |
| | | 1:00PM | vs. | Peru State College | W-9-3 | |
| | Avila Tournament - March 29-30 |
| | 30 | 9:00AM | vs. | University of St. Mary | W-15-0 (5) | |
| | Avila Tournament - March 29-30 |
| | | 1:00PM | vs. | Avila College | W-12-4 (6) | |
| | Avila Tournament - March 29-30 |
| | | 3:00PM | vs. | Harris-Stowe | W-15-1 (5) | |
| | Avila Tournament - March 29-30 |
| | | 5:00PM | vs. | Rodgers State | L-3-5 | |
| | Avila Tournament - March 29-30 |
| April |
| * | 4 | 2:00PM | @ | Columbia | L-0-2 | |
| * | | Game 2 | @ | Columbia | L-2-6 | |
| * | 5 | 12:00PM | vs. | Missouri Baptist | L-0-4 | |
| | at Trenton Park - Trenton, Ill. |
| * | | Game 2 | vs. | Missouri Baptist | W-13-1 (6) | |
| | at Trenton Park - Trenton, Ill. |
| | | 4:00PM | vs. | Robert Morris College | L-0-8 (5) | |
| | McKendree Invitational at Trenton Park - Trenton, Ill. - April 5-6 |
| | 6 | 12:00PM | vs. | University of Saint Francis | W-7-6 | |
| | McKendree Invitational at Trenton Park - Trenton, Ill. |
| * | 14 | 2:00PM | @ | Harris-Stowe | L-2-4 | |
| * | | Game 2 | @ | Harris-Stowe | W-12-0 (5) | |
| | McKendree pitcher Colene Pogue throws two-hitter for sixth win of the season |
| * | 16 | 2:00PM | vs. | Illinois at Springfield | W-4-1 | |
| * | | Game 2 | vs. | Illinois at Springfield | L-3-7 | |
| | 17 | 2:00PM | vs. | Lindenwood University | L-0-3 | |
| | | Game 2 | vs. | Lindenwood University | W-8-2 | |
| | 19 | 1:00PM | vs. | St. Mary's | W-1-0 | |
| | UIS Tournament |
| | | 3:00PM | vs. | University of Saint Francis | W-4-1 | |
| | UIS Tournament |
| | 20 | 1:00PM | vs. | Rodgers State | L-0-7 | |
| | UIS Tournament |
| | | 3:00PM | vs. | Saint Xavier University | L-4-10 | |
| | UIS Tournament |
| | 24 | | vs. | Williams Baptist | L-0-2 (10) | |
| | AMC Tournament - Springfield, Ill. - April 24-26 |
| | | 4:00PM | vs. | Hannibal-LaGrange | W-4-1 | |
| | AMC Tournament - Springfield, Ill. - April 24-26 |
| | 25 | 12:00PM | vs. | Illinois at Springfield | W-1-0 | |
| | 2008 AMC Softball Tournament -- Elimination Bracket |
| | | 4:00PM | vs. | Williams Baptist | L-1-6 | |
| | AMC Tournament - Springfield, Ill. - Elimination Bracket |
