| | Day | Time | | Opponent | Score | |
| March |
| | 1 | 1:00PM | vs. | Avila University | W-8-0 (5) | |
| | | Game 2 | vs. | Avila University | W-12-4 (6) | |
| | 5 | 1:00PM | vs. | Fontbonne University | W-8-0 (5) | |
| | | 3:00PM | vs. | Fontbonne University | W-6-0 | |
| | 16 | 2:00PM | vs. | St. Mary-of-the-Woods College | W-4-1 | |
| | | Game 2 | vs. | St. Mary-of-the-Woods College | L-4-6 | |
| * | 17 | 2:00PM | vs. | Williams Baptist | L-2-5 | |
| * | | Game 2 | vs. | Williams Baptist | W-8-4 | |
| | 19 | 4:00PM | @ | Lindenwood University | L-1-2 | |
| | | Game 2 | @ | Lindenwood University | L-5-12 | |
| | 21 | 9:00AM | vs. | Baker University | L-6-7 | |
| | Avila Tournament |
| | | 11:00AM | vs. | Graceland University | W-3-1 | |
| | Avila Tournament |
| | | 7:00PM | vs. | Saint Gregory's University | L-1-10 | |
| | Avila Tournament |
| | 22 | 1:00PM | vs. | Rogers State University | L-2-9 | |
| | Avila Tournament |
| | | 3:00PM | vs. | University of St. Mary | W-5-2 | |
| | Avila Tournament |
| * | 26 | 2:00PM | @ | Hannibal-LaGrange | L-5-6 (8) | |
| * | | Game 2 | @ | Hannibal-LaGrange | W-9-0 | |
| | 28 | 10:00AM | vs. | McKendree | RAIN | |
| | at Forest Park Community College |
| | | Game 2 | vs. | McKendree | RAIN | |
| | at Forest Park Community College |
| | 30 | 1:00PM | vs. | Ashford University | RAIN | |
| | | Game 2 | vs. | Ashford University | RAIN | |
| * | 31 | 2:00PM | @ | Missouri Baptist | L-2-3 (8) | |
| * | | Game 2 | @ | Missouri Baptist | L-5-6 | |
| April |
| | 10 | 12:00PM | vs. | Iowa Wesleyan College | L-4-7 (10) | |
| | Iowa Wesleyan Tournament |
| | | 3:30PM | vs. | University of Saint Francis | W-5-4 (8) | |
| | Iowa Wesleyan Tournament |
| | | 5:15PM | vs. | Judson College | L-3-4 (11) | |
| | Iowa Wesleyan Tournament |
| | 11 | 9:00AM | vs. | Trinity International University | W-8-5 | |
| | Iowa Wesleyan Tournament |
| | | 10:45AM | vs. | Purdue University-North Central | L-0-4 | |
| | Iowa Wesleyan Tournament |
| * | 14 | 2:00PM | @ | William Woods | L-0-8 (5) | |
| * | | Game 2 | @ | William Woods | L-4-11 | |
| * | 15 | 1:00PM | vs. | Stephens | W-1-0 | |
| * | | Game 2 | vs. | Stephens | W-12-1 (5) | |
| | 18 | 10:00AM | vs. | Robert Morris College | L-0-2 | |
| | University of Illinois-Springfield Tournament |
| | | 2:00PM | vs. | Cardinal Stritch University | W-2-1 | |
| | University of Illinois-Springfield Tournament |
| | 22 | 2:30PM | @ | St. Mary-of-the-Woods College | W-7-5 | |
| | | Game 2 | @ | St. Mary-of-the-Woods College | L-1-2 | |
| * | 24 | 2:00PM | vs. | Columbia | L-0-4 | |
| * | | Game 2 | vs. | Columbia | W-6-3 | |
| * | 25 | 12:00PM | vs. | McKendree | L-2-6 | |
| | at Forest Park Community College |
| * | | Game 2 | vs. | McKendree | L-0-6 | |
| * | 29 | 12:00PM | vs. | University of Illinois at Springfield | W-8-0 | |
| | Harris-Stowe wins by forfeit |
| * | | Game 2 | vs. | University of Illinois at Springfield | W-8-0 | |
| | Harris-Stowe wins by forfeit |
| May |
| | 1 | 2:00PM | vs. | Williams Baptist | W-5-1 | |
| | 2009 AMC Softball Tournament -- First Round |
| | 2 | 1:00PM | vs. | William Woods | L-1-15 (5) | |
| | 2009 AMC Softball Tournament |
| | | 3:00PM | vs. | McKendree | L-2-5 | |
| | AMC Tournament - Jefferson City, Mo. |
