| | Day | Time | | Opponent | Score | |
| February |
| | 20 | 4:00PM | @ | Martin Methodist | L-4-5 | |
| | Martin Methodist Spring Meltdown Tournament |
| | | Game 2 | @ | Martin Methodist | L-4-9 | |
| | Martin Methodist Spring Meltdown Tournament |
| | 21 | 11:00AM | vs. | Freed-Hardeman | W-3-1 | |
| | Martin Methodist Spring Meltdown Tournament |
| | | 1:00PM | vs. | UVA-Wise | L-0-1 | |
| | Martin Methodist Spring Meltdown Tournament |
| | 27 | 10:00AM | vs. | William Jewell College | L-0-9 | |
| | Evangel Early Bird Tournament |
| | | 11:45AM | vs. | College of Saint Mary | W-7-6 | |
| | Evangel Early Bird Tournament |
| | | 6:45PM | vs. | Midland Lutheran College | W-3-0 | |
| | Evangel Early Bird Tournament |
| March |
| * | 5 | 2:00PM | @ | Williams Baptist | L-1-4 | |
| * | | Game 2 | @ | Williams Baptist | L-0-5 | |
| | 14 | 10:00AM | vs. | Dordt College | W-12-5 | |
| | OBU Lady Bison Classic - Shawnee, Okla. |
| | | 4:00PM | @ | Oklahoma Baptist University | W-3-2 (8) | |
| | OBU Lady Bison Classic - Shawnee, Okla. |
| * | 18 | 2:00PM | @ | Missouri Baptist | W-3-1 | |
| * | | Game 2 | @ | Missouri Baptist | W-3-2 | |
| | 21 | 11:00AM | vs. | Peru State College | W-4-0 | |
| | Avila University Dennis Gault Tournament - Blue Spring, Mo. |
| | | 3:00PM | vs. | Calumet College of St. Joseph | W-3-0 | |
| | Avila University Dennis Gault Tournament - Blue Spring, Mo. |
| | 22 | 9:00AM | vs. | University of St. Mary | W-13-1 (6) | |
| | Avila University Dennis Gault Tournament - Blue Spring, Mo. |
| | | 11:00AM | vs. | Graceland University | W-5-1 | |
| | Avila University Dennis Gault Tournament - Blue Spring, Mo. |
| | | 3:00PM | vs. | Rogers State University | W-2-1 (8) | |
| | Avila University Dennis Gault Tournament - Blue Spring, Mo. |
| | | 5:00PM | vs. | Saint Gregory's University | L-0-8 | |
| | Avila University Dennis Gault Tournament - Blue Spring, Mo. |
| | 26 | 2:00PM | vs. | Lindenwood University | L-1-4 | |
| | | Game 2 | vs. | Lindenwood University | L-0-2 | |
| | 28 | 10:00AM | @ | Harris-Stowe | RAIN | |
| | at Forest Park Community College |
| | | Game 2 | @ | Harris-Stowe | RAIN | |
| | at Forest Park Community College |
| April |
| * | 1 | 3:00PM | vs. | William Woods | W-12-4 (5) | |
| * | | Game 2 | vs. | William Woods | W-4-2 | |
| * | 3 | Game 2 | vs. | Columbia | L-1-6 | |
| * | | 2:30PM | vs. | Columbia | L-1-2 | |
| | 4 | 1:00PM | vs. | Robert Morris College | L-1-2 | |
| | McKendree Invitational - April 4-5 |
| | | 5:00PM | vs. | Spalding University | W-2-1 | |
| | McKendree Invitational - April 4-5 |
| * | 8 | 2:00PM | @ | University of Illinois at Springfield | W-12-2 | |
| * | | Game 2 | @ | University of Illinois at Springfield | W-1-0 | |
| | 9 | 3:00PM | vs. | Culver-Stockton College | RAIN | |
| | | Game 2 | vs. | Culver-Stockton College | RAIN | |
| * | 15 | 2:00PM | @ | Hannibal-LaGrange | W-4-3 | |
| * | | Game 2 | @ | Hannibal-LaGrange | W-1-0 | |
| | 18 | 12:00PM | vs. | Calumet College of St. Joseph | W-6-1 | |
| | University of Illinois at Springfield Tournament |
| | | 4:00PM | vs. | Saint Xavier University | L-4-8 | |
| | University of Illinois at Springfield Tournament |
| * | 21 | 3:00PM | vs. | Stephens | W-4-3 | |
| * | | Game 2 | vs. | Stephens | W-4-0 | |
| * | 25 | 12:00PM | @ | Harris-Stowe | W-6-2 | |
| | at Forest Park Community College |
| * | | Game 2 | @ | Harris-Stowe | W-6-0 | |
| May |
| | 1 | 9:00PM | vs. | Missouri Baptist | L-0-3 | |
| | 2009 AMC Softball Tournament -- First Round |
| | 2 | 11:00AM | vs. | Hannibal-LaGrange | W-7-6 | |
| | AMC Tournament at William Woods University |
| | | 3:00PM | vs. | Harris-Stowe | W-5-2 | |
| | AMC Tournament - Jefferson City, Mo. |
| | | 5:00PM | vs. | Missouri Baptist | W-5-0 | |
| | AMC Tournament - Jefferson City, Mo. |
| | 3 | 12:00PM | vs. | William Woods | W-9-6 | |
| | AMC Tournament - Jefferson City, Mo. |
| | | 2:00PM | vs. | Columbia | W-3-0 | |
| | | 4:30PM | vs. | Columbia | W-7-4 | |
| | McKendree wins AMC Championship |
| | 14 | 2:30PM | vs. | Madonna University | L-1-3 | |
| | NAIA Softball National Championship -- Pool Play -- Decatur, Ala. |
| | 15 | 1:00PM | vs. | Point Loma Nazarene University | L-0-4 | |
| | NAIA Softball National Championship -- Pool Play -- Decatur, Ala. |
| | 17 | 8:00PM | vs. | Holy Names College | L-5-6 (8) | |
| | NAIA Softball National Championship -- Pool Play -- Decatur, Ala. |
