| | Day | Time | | Opponent | Score | |
| October |
| | 30 | 8:00PM | @ | Freed-Hardeman University | L-73-103 | |
| | Freed-Hardeman Tournament |
| | 31 | 2:00PM | vs. | Blue Mountain College | W-101-95 | |
| | Freed-Hardeman Tournament |
| November |
| | 5 | 7:00PM | @ | Southeast Missouri State University | L-67-75 | |
| | 13 | 5:00PM | vs. | Union University | L-62-75 | |
| | McKendree Tournament |
| | 14 | 5:00PM | vs. | East-West University | W-83-69 | |
| | McKendree Tournament |
| | 17 | 7:00PM | @ | Maryville University-St. Louis | W-86-71 | |
| | 21 | 7:30PM | @ | Southern Indiana | L-61-84 | |
| December |
| | 8 | 7:00PM | vs. | Logan Chiropractic | W-86-20 | |
| | 9 | 7:00PM | @ | Blackburn College | W-71-46 | |
| | 11 | 8:00PM | @ | Bethel College | W-74-64 | |
| | Bethel College Classic |
| | 12 | 2:00PM | vs. | Lindsey Wilson | W-77-70 | |
| | Bethel College Classic |
| | 21 | | vs. | Saint Xavier University | W-65-53 | |
| | Saint Xavier Tournament-Dec. 21-23 |
| | 22 | 6:00PM | vs. | Aquinas College | L-57-62 | |
| | Saint Xavier Tournament-Dec. 21-23 |
| | 23 | 4:00PM | vs. | Siena Heights University | L-55-65 | |
| | Saint Xavier Tournament-Dec. 21-23 |
| January |
| | 4 | 7:00PM | @ | Missouri Valley College | L-75-83 | |
| * | 9 | 4:00PM | @ | William Woods | L-61-76 | |
| * | 14 | 7:30PM | @ | Missouri Baptist | W-71-68 | |
| * | 16 | 4:00PM | vs. | Hannibal-LaGrange | W-74-54 | |
| * | 19 | 7:30PM | vs. | Park | L-65-68 | |
| * | 23 | 4:00PM | vs. | McKendree | L-66-74 | |
| * | 28 | 7:30PM | vs. | Columbia | W-55-47 | |
| * | 30 | 4:00PM | @ | Williams Baptist | PPD | |
| | Postponed -- Rescheduled for Monday, Feb. 1 at 7:30 p.m. |
| February |
| * | 1 | 7:30PM | @ | Williams Baptist | W-84-56 | |
| | Rescheduled from Saturday, Jan. 30 |
| * | 6 | 4:00PM | vs. | William Woods | W-72-65 | |
| | 9 | 7:00PM | vs. | Blackburn College | W-85-49 | |
| * | 11 | 7:30PM | vs. | Missouri Baptist | L-80-82 | |
| * | 13 | 4:00PM | @ | Hannibal-LaGrange | L-72-82 | |
| * | 16 | 7:30PM | @ | Park | L-61-93 | |
| * | 20 | 4:00PM | @ | McKendree | L-64-67 | |
| | Brad Copelin joins McKendree's 1,000-Point Club |
| * | 25 | 7:30PM | @ | Columbia | L-57-65 | |
| * | 27 | 4:00PM | vs. | Williams Baptist | W-71-41 | |
| March |
| | 4 | 7:00PM | @ | Missouri Baptist | W-77-68 | |
| | AMC Tournament Quarterfinal |
| | 6 | 4:00PM | @ | Park | L-47-62 | |
| | 2010 American Midwest Conference Men's Tournament -- Semifinals |