| | Day | Time | | Opponent | Score | |
| October |
| | 31 | 7:00PM | vs. | Trinity International University | W-83-73 | |
| November |
| | 4 | 7:00PM | vs. | Lindenwood University | W-73-62 | |
| | 7 | 4:00PM | vs. | Ohio Dominican University | W-65-53 | |
| | Career Victory No. 998 for McKendree head coach Harry Statham |
| | 10 | 7:00PM | @ | Graceland University | W-71-59 | |
| | McKendree coach Harry Statham earns career victory No. 999 |
| | 13 | 7:00PM | vs. | East-West University | W-79-49 | |
| | Harry Statham becomes the first coach in men's college basketball history at a four-year institution to win 1,000 career games |
| | 14 | 7:00PM | vs. | Union University | L-64-66 | |
| | McKendree Classic |
| | 18 | 7:00PM | @ | Indiana University-South Bend | W-80-57 | |
| | 24 | 7:00PM | vs. | Graceland University | W-93-65 | |
| | 27 | 7:00PM | @ | Union University | L-60-68 | |
| | Union Thanksgiving Classic |
| | 28 | 2:00PM | vs. | Freed-Hardeman | W-74-63 | |
| | Union Thanksgiving Classic |
| December |
| | 4 | 8:00PM | @ | Washington University | L-67-82 | |
| | Washington University Lopata Classic -- Semifinals |
| | 5 | 6:00PM | vs. | Whitworth College | L-69-72 | |
| | Washington University Lopata Classic -- Consolation |
| | 8 | 7:00PM | vs. | Olivet Nazarene University | W-78-72 | |
| | 12 | 3:00PM | @ | Saint Ambrose University | L-76-83 | |
| | 15 | 7:00PM | @ | Concordia Seminary-St. Louis | W-84-38 | |
| January |
| | 2 | 3:00PM | @ | Ohio Dominican University | W-72-70 | |
| * | 7 | 7:30PM | vs. | William Woods | W-89-61 | |
| * | 9 | 4:00PM | @ | Hannibal-LaGrange | W-74-59 | |
| * | 14 | 7:30PM | @ | Columbia | W-80-71 | |
| * | 16 | 4:00PM | vs. | Missouri Baptist | W-85-60 | |
| * | 23 | 4:00PM | @ | Harris-Stowe | W-74-66 | |
| * | 28 | 7:30PM | vs. | Williams Baptist | PPD | |
| | Postponed -- Rescheduled for Tuesday, Feb. 16 |
| * | 30 | 4:00PM | @ | Park | W-80-74 | |
| February |
| * | 4 | 7:30PM | @ | William Woods | W-79-69 | |
| * | 6 | 4:00PM | vs. | Hannibal-LaGrange | W-71-60 | |
| * | 11 | 7:30PM | vs. | Columbia | W-71-41 | |
| * | 13 | 4:00PM | @ | Missouri Baptist | L-78-81 | |
| | The Spartans upset the NAIA #7 Bearcats |
| * | 16 | 6:00PM | vs. | Williams Baptist | W-80-55 | |
| | Rescheduled from Thursday, Jan. 28 |
| * | 20 | 4:00PM | vs. | Harris-Stowe | W-67-64 | |
| | Brad Copelin joins McKendree's 1,000-Point Club |
| * | 25 | 7:30PM | @ | Williams Baptist | W-82-56 | |
| * | 27 | 4:00PM | vs. | Park | W-71-55 | |
| March |
| | 4 | 7:00PM | vs. | William Woods | W-79-53 | |
| | 2010 American Midwest Conference Men's Tournament -- Quarterfinals |
| | 6 | 4:00PM | vs. | Columbia | W-72-44 | |
| | 2010 American Midwest Conference Men's Tournament -- Semifinals |
| | 9 | 7:00PM | vs. | Park | W-84-66 | |
| | 2010 American Midwest Conference Men's Tournament -- Championship |
| | 17 | 2:15PM | vs. | John Brown University | L-70-73 (OT) | |
| | 2010 Buffalo Funds-NAIA Division I Men's Basketball National Championship -- First Round |
