| | Day | Time | | Opponent | Score | |
| November |
| | 2 | 7:00PM | @ | Union University | L-69-96 | |
| | 9 | 5:30PM | vs. | Avila University | W-77-61 | |
| | 13 | 7:00PM | @ | Lindenwood University | W-99-52 | |
| | 17 | 7:00PM | @ | Ottawa University | W-77-60 | |
| | 21 | 2:00PM | vs. | Baker University | W-64-56 | |
| | 24 | 5:30PM | vs. | Freed-Hardeman University | W-85-60 | |
| | The No. 14 ranked Lady Cougars upset No. 6 ranked Freed-Hardeman |
| | 28 | 2:00PM | @ | Lyon College | W-61-57 | |
| | 30 | 7:00PM | vs. | Benedictine College | W-69-52 | |
| December |
| | 3 | 5:30PM | @ | Dillard | W-73-59 | |
| | 5 | 2:00PM | @ | Loyola University | W-81-65 | |
| January |
| | 1 | 6:00PM | vs. | Lyon College | W-65-57 | |
| | | 6:00PM | vs. | Campbellsville University | | |
| | 2 | 6:00PM | vs. | Missouri Valley College | W-78-49 | |
| | 4 | 5:00PM | @ | McPherson College | W-74-44 | |
| * | 7 | 5:30PM | @ | Williams Baptist | W-76-67 | |
| * | 9 | 2:00PM | vs. | Park | W-67-48 | |
| * | 14 | 5:30PM | vs. | McKendree | W-83-59 | |
| * | 16 | 2:00PM | @ | Stephens | W-90-56 | |
| * | 19 | 5:30PM | @ | Hannibal-LaGrange | W-96-82 | |
| * | 21 | 5:30PM | vs. | Missouri Baptist | W-103-82 | |
| | Columbia Ranked #8 in NAIA Dvision I |
| | 25 | 7:00PM | @ | Peru State College | L-63-65 | |
| * | 28 | 5:30PM | @ | Harris-Stowe | W-70-38 | |
| * | 30 | 2:00PM | vs. | William Woods | W-68-63 | |
| February |
| * | 4 | 5:30PM | vs. | Williams Baptist | W-87-59 | |
| * | 6 | 2:00PM | @ | Park | W-65-41 | |
| * | 11 | 5:30PM | @ | McKendree | L-59-76 | |
| * | 13 | 2:00PM | vs. | Stephens | W-85-64 | |
| * | 16 | 5:30PM | vs. | Hannibal-LaGrange | W-83-64 | |
| * | 18 | 5:30PM | @ | Missouri Baptist | W-85-53 | |
| | Lady Cougars #10 in NAIA |
| * | 25 | 5:30PM | vs. | Harris-Stowe | W-98-53 | |
| * | 27 | 2:00PM | @ | William Woods | L-66-69 | |
| March |
| | 3 | 7:00PM | vs. | Park | W-96-60 | |
| | 2010 American Midwest Conference Women's Tournament -- Quarterfinals |
| | 5 | 7:00PM | vs. | Williams Baptist | W-95-63 | |
| | 2010 American Midwest Conference Women's Tournament -- Semifinals |
| | 8 | 7:00PM | @ | William Woods | L-56-66 | |
| | 2010 American Midwest Conference Women's Tournament -- Championship |