| | Day | Time | | Opponent | Score | |
| November |
| | 4 | 8:00PM | vs. | Saint Louis College of Pharmacy | W-105-38 | |
| | 7 | 2:00PM | vs. | Calumet College of St. Joseph | W-83-54 | |
| | 12 | 7:00PM | vs. | Culver-Stockton College | W-81-66 | |
| | 18 | 7:30PM | @ | Lindenwood University | W-107-97 | |
| | Megan Payton sets new MBU single game scoring record with 48 points. |
| | 21 | 2:00PM | vs. | Heidelberg University | W-71-56 | |
| | 24 | 6:00PM | vs. | Greenville College | W-80-54 | |
| December |
| | 1 | 5:00PM | vs. | Illinois Wesleyan | L-62-75 | |
| | 4 | 8:00PM | @ | Millikin University | W-81-68 | |
| | Millikin University Harriett CrannellTournament |
| | 5 | 3:00PM | vs. | Luther College | W-77-70 | |
| | Milliken University Harriett Crannell Tournament |
| | 16 | 5:00PM | vs. | Saint Thomas University | L-56-65 | |
| | Northwood University (FL) Classic |
| | 17 | 7:00PM | @ | Northwood University | L-80-99 | |
| | Northwood University (FL) Classic |
| | 30 | 6:00PM | vs. | Missouri-St. Louis | L-44-68 | |
| January |
| * | 9 | 2:00PM | vs. | Stephens | W-75-66 | |
| * | 14 | 5:30PM | vs. | Harris-Stowe | W-112-72 | |
| * | 16 | 2:00PM | @ | McKendree | L-54-73 | |
| * | 21 | 5:30PM | @ | Columbia | L-82-103 | |
| | Columbia Ranked #8 in NAIA Dvision I |
| * | 23 | 2:00PM | vs. | Williams Baptist | L-80-83 | |
| * | 26 | 5:30PM | @ | Park | W-86-57 | |
| | Rescheduled from Jan. 7 |
| * | 28 | 5:30PM | @ | William Woods | L-70-85 | |
| * | 30 | 2:00PM | vs. | Hannibal-LaGrange | W-69-60 (OT) | |
| February |
| * | 4 | 5:30PM | vs. | Park | W-75-74 (2OT) | |
| * | 6 | 2:00PM | @ | Stephens | W-70-66 | |
| * | 11 | 5:30PM | @ | Harris-Stowe | W-80-66 | |
| * | 13 | 2:00PM | vs. | McKendree | L-59-79 | |
| * | 18 | 5:30PM | vs. | Columbia | L-53-85 | |
| | Lady Cougars #10 in NAIA |
| * | 20 | 2:00PM | @ | Williams Baptist | L-80-86 | |
| * | 25 | 5:30PM | vs. | William Woods | L-68-78 | |
| | Senior Night |
| * | 27 | 2:00PM | @ | Hannibal-LaGrange | W-90-84 | |
| | Senior Day |
| March |
| | 3 | 7:00PM | vs. | Hannibal-LaGrange | W-77-65 | |
| | AMC Tournament Quarterfinal |
| | 5 | 7:00PM | @ | William Woods | L-57-69 | |
| | 2010 American Midwest Conference Women's Tournament -- Semifinals |