| | Day | Time | | Opponent | Score | |
| November |
| | 3 | 7:00PM | vs. | Culver-Stockton College | L-49-54 | |
| | 6 | | vs. | Manhattan Christian College | W-69-55 | |
| | St. Louis Pharmacy Classic - November 6-7 |
| | 7 | 1:00PM | vs. | Baptist Bible College | W-83-53 | |
| | St. Louis Pharmacy Classic |
| | 13 | 6:00PM | vs. | McPherson College | L-55-56 | |
| | Maui Midwest Classic hosted by University of St. Mary |
| | 14 | 8:30PM | @ | University of St. Mary | W-63-57 | |
| | Maui Midwest Classic hosted by University of St. Mary |
| | 20 | 8:00PM | vs. | Bethel College | L-58-62 | |
| | Tip Off Classic |
| | 21 | 3:00PM | vs. | University of St. Mary | W-59-40 | |
| | Tip Off Classic |
| | 24 | 6:00PM | @ | Westminster College | W-72-53 | |
| December |
| | 2 | 7:00PM | vs. | Saint Louis College of Pharmacy | W-83-29 | |
| | 8 | 7:00PM | vs. | Principia College | W-53-39 | |
| | 12 | 2:00PM | @ | William Penn College | L-40-77 | |
| January |
| * | 9 | 2:00PM | @ | Missouri Baptist | L-66-75 | |
| * | 12 | 7:00PM | @ | Williams Baptist | L-52-58 | |
| * | 16 | 2:00PM | vs. | Columbia | L-56-90 | |
| * | 19 | 7:00PM | @ | McKendree | L-54-75 | |
| * | 21 | 7:00PM | vs. | Harris-Stowe | W-79-71 | |
| * | 23 | 2:00PM | @ | William Woods | L-60-74 | |
| * | 26 | 7:00PM | vs. | Hannibal-LaGrange | L-54-66 | |
| | rescheduled from January 7th |
| * | 28 | 7:00PM | vs. | Park | L-58-67 | |
| February |
| * | 4 | 7:00PM | @ | Hannibal-LaGrange | L-63-72 | |
| * | 6 | 2:00PM | vs. | Missouri Baptist | L-66-70 | |
| * | 11 | 7:00PM | vs. | Williams Baptist | L-81-89 (OT) | |
| * | 13 | 2:00PM | @ | Columbia | L-64-85 | |
| * | 16 | 7:00PM | vs. | McKendree | L-50-71 | |
| * | 18 | 7:00PM | @ | Harris-Stowe | L-73-78 | |
| * | 20 | 2:00PM | vs. | William Woods | L-51-73 | |
| | Senior Day |
| * | 25 | 7:00PM | @ | Park | L-54-75 | |
| | Senior Night |
| March |
| | 1 | 7:00PM | @ | Harris-Stowe | W-62-53 | |
| | AMC Tournament Play-In Game |
| | 3 | 7:00PM | @ | William Woods | L-52-64 | |
| | 2010 American Midwest Conference Women's Tournament -- Quarterfinals. Tia LaFavor scores her 1000th point for Stephens College. |