| | Day | Time | | Opponent | Score | |
| November |
| | 6 | 1:00PM | vs. | Avila University | L-65-84 | |
| | Tipoff Classic - Olathe, Kan. |
| | 7 | 6:00PM | vs. | MidAmerica Nazarene University | L-43-51 | |
| | MNU Classic - Olathe, Kan. |
| | 10 | 5:30PM | vs. | Missouri Valley College | L-43-46 | |
| | 13 | | @ | Baker University | L-50-80 | |
| | Baker Classic - Baldwin City, Kan. |
| | 14 | | vs. | Benedictine College | L-61-62 (OT) | |
| | Baker Classic - Baldwin City, Kan. |
| | 17 | 7:00PM | vs. | William Jewell College | L-41-81 | |
| | 21 | 1:00PM | vs. | Kansas Wesleyan University | L-53-63 | |
| | 24 | 5:30PM | @ | Missouri Valley College | L-54-66 | |
| | 28 | 1:00PM | vs. | Friends University | W-59-53 | |
| December |
| | 1 | 7:00PM | vs. | MidAmerica Nazarene University | L-54-64 | |
| | 5 | 2:00PM | vs. | Langston University | L-51-56 | |
| January |
| | 2 | 2:00PM | vs. | Benedictine College | L-40-55 | |
| * | 9 | 2:00PM | @ | Columbia | L-48-67 | |
| * | 15 | 5:30PM | @ | Williams Baptist | L-60-63 | |
| * | 16 | 2:00PM | @ | Williams Baptist | L-62-84 | |
| * | 19 | 5:30PM | @ | Harris-Stowe | W-68-42 | |
| * | 21 | 5:30PM | vs. | William Woods | L-56-66 | |
| * | 23 | 2:00PM | @ | Hannibal-LaGrange | L-65-68 | |
| * | 26 | 5:30PM | vs. | Missouri Baptist | L-57-86 | |
| | Rescheduled from Jan. 7 |
| * | 28 | 7:00PM | @ | Stephens | W-67-58 | |
| * | 30 | 2:00PM | vs. | McKendree | L-43-74 | |
| February |
| * | 4 | 5:30PM | @ | Missouri Baptist | L-74-75 (2OT) | |
| * | 6 | 2:00PM | vs. | Columbia | L-41-65 | |
| | 9 | 7:00PM | vs. | College of the Ozarks | L-65-73 | |
| * | 16 | 5:30PM | vs. | Harris-Stowe | W-77-62 | |
| * | 18 | 5:30PM | @ | William Woods | L-66-80 | |
| * | 20 | 2:00PM | vs. | Hannibal-LaGrange | L-54-64 | |
| * | 25 | 7:00PM | vs. | Stephens | W-75-54 | |
| | Senior Night |
| * | 27 | 2:00PM | @ | McKendree | L-75-81 | |
| March |
| | 3 | 7:00PM | @ | Columbia | L-60-96 | |
| | 2010 American Midwest Conference Women's Tournament -- Quarterfinals |