| | Day | Time | | Opponent | Score | |
| October |
| | 30 | 5:00PM | vs. | Hannibal-LaGrange | W-62-55 | |
| | 31 | 2:00PM | vs. | Brescia University | L-69-72 | |
| | | 3:00PM | vs. | Hannibal-LaGrange | W-67-59 | |
| November |
| | 2 | 6:00PM | vs. | McKendree | L-73-75 | |
| | McKendree University upsets No. 20 Bethel University (Tenn.) |
| | | 7:00PM | vs. | Williams Baptist | L-63-86 | |
| | | 7:00PM | vs. | Columbia | W-96-69 | |
| | 3 | 7:00PM | vs. | Culver-Stockton College | L-49-54 | |
| | 4 | 8:00PM | vs. | Saint Louis College of Pharmacy | W-105-38 | |
| | 5 | 5:30PM | vs. | Culver-Stockton College | W-1-0 | |
| | Harris-Stowe wins due to violation by Culver-Stockton |
| | 6 | | vs. | Stephens | L-55-69 | |
| | St. Louis Pharmacy Classic - November 6-7 |
| | | 1:00PM | vs. | Park | W-84-65 | |
| | Tipoff Classic - Olathe, Kan. |
| | | 5:30PM | vs. | Calumet College of St. Joseph | L-76-83 | |
| | | 7:00PM | vs. | William Penn University | W-79-72 | |
| | 7 | 1:00PM | vs. | Stephens | L-53-83 | |
| | St. Louis Pharmacy Classic |
| | | 2:00PM | vs. | Calumet College of St. Joseph | W-83-54 | |
| | | 2:00PM | vs. | Ecclesia College | W-85-77 | |
| | | 4:00PM | vs. | Missouri Valley College | W-78-66 | |
| | Homecoming |
| | | 6:00PM | vs. | Park | W-51-43 | |
| | MNU Classic - Olathe, Kan. |
| | | 7:00PM | vs. | Saint Xavier University | L-61-78 | |
| | 9 | 5:30PM | vs. | Avila University | W-77-61 | |
| | | 7:00PM | vs. | Mid-Continent College | W-89-27 | |
| | 10 | 5:30PM | vs. | Missouri Valley College | L-43-46 | |
| | | 5:30PM | vs. | William Woods | L-53-58 | |
| | | 5:30PM | vs. | Bethel College | L-53-65 | |
| | | 6:00PM | vs. | Williams Baptist | L-77-84 | |
| | | 7:00PM | vs. | Hannibal-LaGrange | L-40-57 | |
| | 12 | 5:00PM | vs. | Lyon College | L-64-79 | |
| | | 5:30PM | vs. | McKendree | W-78-62 | |
| | | 7:00PM | vs. | Culver-Stockton College | W-81-66 | |
| | 13 | | vs. | Park | W-80-50 | |
| | Baker Classic - Baldwin City, Kan. |
| | | 6:00PM | vs. | Stephens | W-56-55 | |
| | Maui Midwest Classic hosted by University of St. Mary |
| | | 7:00PM | vs. | Columbia | L-52-99 | |
| | 14 | | vs. | Park | W-62-61 (OT) | |
| | Baker Classic - Baldwin City, Kan. |
| % | | 1:00PM | vs. | Hannibal-LaGrange | W-61-53 | |
| | | 5:30PM | vs. | McKendree | L-58-62 | |
| | | 8:30PM | vs. | Stephens | L-57-63 | |
| | Maui Midwest Classic hosted by University of St. Mary |
| | 15 | 3:00PM | vs. | Harris-Stowe | W-84-63 | |
| | 16 | 5:30PM | vs. | Central Methodist University | W-67-60 | |
| | 17 | 7:00PM | vs. | Bethel College | W-75-59 | |
| | | 7:00PM | vs. | William Jewell College | L-41-81 | |
| | | 7:00PM | vs. | Columbia | L-60-77 | |
| | | 7:00PM | vs. | Williams Baptist | L-84-89 | |
| % | | 7:30PM | vs. | Hannibal-LaGrange | W-58-54 | |
| | 18 | 7:00PM | vs. | William Woods | L-47-58 | |
| | | 7:30PM | vs. | Missouri Baptist | L-97-107 | |
| | Megan Payton sets new MBU single game scoring record with 48 points. |
| | 19 | 5:30PM | vs. | Blue Mountain College | W-82-77 | |
| | | 7:00PM | vs. | McKendree | L-63-65 | |
| | 20 | 2:00PM | vs. | Harris-Stowe | W-85-70 | |
| | Bethel Classic |
| | | 8:00PM | vs. | Bethel College | L-58-62 | |
| | Tip Off Classic |
| | 21 | 12:00PM | vs. | Harris-Stowe | W-77-56 | |
| | Bethel Classic |
| | | 1:00PM | vs. | Kansas Wesleyan University | L-53-63 | |
| | | 2:00PM | vs. | Baker University | W-64-56 | |
| | | 2:00PM | vs. | Heidelberg University | W-71-56 | |
| | | 2:00PM | vs. | Ottawa University | W-82-64 | |
| | | 3:00PM | vs. | University of St. Mary | W-59-40 | |
| | Tip Off Classic |
| | | 7:30PM | vs. | Hannibal-LaGrange | W-69-63 | |
| | 23 | 5:30PM | vs. | Central Methodist University | L-39-55 | |
| | 24 | 4:00PM | vs. | Williams Baptist | L-46-74 | |
| | | 5:00PM | vs. | McKendree | L-52-56 | |
| | | 5:30PM | vs. | Park | W-66-54 | |
| | | 5:30PM | vs. | Freed-Hardeman University | W-85-60 | |
| | The No. 14 ranked Lady Cougars upset No. 6 ranked Freed-Hardeman |
| | | 5:30PM | vs. | Lincoln University | L-50-64 | |
| | | 6:00PM | vs. | Greenville College | W-80-54 | |
| | | 6:00PM | vs. | Stephens | L-53-72 | |
| | | 6:00PM | vs. | University of St. Mary | W-65-37 | |
| | | 7:00PM | vs. | Blackburn College | W-79-46 | |
| | 27 | 6:00PM | vs. | McKendree | W-91-81 (OT) | |
| | 28 | 1:00PM | vs. | Friends University | W-59-53 | |
| | | 2:00PM | vs. | McKendree | L-70-73 | |
| | | 2:00PM | vs. | Columbia | L-57-61 | |
| | | 3:00PM | vs. | Hannibal-LaGrange | W-76-70 | |
| | 30 | 7:00PM | vs. | Benedictine College | W-69-52 | |
| | | 7:00PM | vs. | William Woods | L-49-64 | |
| % | | 7:00PM | vs. | Hannibal-LaGrange | W-84-63 | |
| December |
| | 1 | 5:00PM | vs. | Illinois Wesleyan | L-62-75 | |
| | | 7:00PM | vs. | McKendree | L-72-96 | |
| | | 7:00PM | vs. | MidAmerica Nazarene University | L-54-64 | |
| | 2 | 7:00PM | vs. | Saint Louis College of Pharmacy | W-83-29 | |
| | | 7:00PM | vs. | Westminster College | W-72-59 | |
| | 3 | 5:30PM | vs. | Columbia | L-59-73 | |
| | | 6:00PM | vs. | Williams Baptist | W-75-64 | |
| | 4 | 7:00PM | vs. | University of Saint Francis | W-81-71 | |
| | | 7:00PM | vs. | Hannibal-LaGrange | W-79-40 | |
| | | 7:00PM | vs. | Williams Baptist | W-87-85 (OT) | |
| | CBC Classic |
| | | 8:00PM | vs. | Missouri Baptist | L-68-81 | |
| | Millikin University Harriett CrannellTournament |
| | 5 | | vs. | Williams Baptist | L-59-66 | |
| | CBC Classic |
| | | 2:00PM | vs. | Langston University | L-51-56 | |
| | | 2:00PM | vs. | Columbia | L-65-81 | |
| | | 3:00PM | vs. | Missouri Baptist | L-70-77 | |
| | Milliken University Harriett Crannell Tournament |
| | | 4:00PM | vs. | Hannibal-LaGrange | W-66-54 | |
| | | 6:00PM | vs. | William Woods | L-57-62 | |
| | 8 | 7:00PM | vs. | Principia College | W-53-39 | |
| | | 7:00PM | vs. | Central Methodist University | L-56-65 | |
| | 12 | 2:00PM | vs. | Stephens | W-77-40 | |
| | | 2:00PM | vs. | Baker University | W-72-54 | |
| | | 2:00PM | vs. | Philander Smith College | L-65-69 | |
| | | 5:00PM | vs. | Iowa Wesleyan College | W-83-65 | |
| | 14 | 7:00PM | vs. | Harris-Stowe | W-88-49 | |
| | 16 | 5:00PM | vs. | Missouri Baptist | W-65-56 | |
| | Northwood University (FL) Classic |
| | 17 | 7:00PM | vs. | Missouri Baptist | W-99-80 | |
| | Northwood University (FL) Classic |
| | 19 | 2:00PM | vs. | Benedictine College | L-68-69 | |
| | 30 | 3:00PM | vs. | Williams Baptist | W-90-70 | |
| | | 6:00PM | vs. | Missouri-St. Louis | L-44-68 | |
| January |
| | 1 | 2:00PM | vs. | William Woods | L-55-72 | |
| | Cougars vs. Cancer Classic |
| | | 6:00PM | vs. | Lyon College | W-65-57 | |
| | | 6:00PM | vs. | Campbellsville University | | |
| | 2 | 2:00PM | vs. | Avila University | W-83-56 | |
| | | 2:00PM | vs. | Benedictine College | L-40-55 | |
| | | 2:00PM | vs. | William Woods | L-62-73 | |
| | Cougars vs. Cancer Classic |
| | | 6:00PM | vs. | Missouri Valley College | W-78-49 | |
| | 4 | 5:00PM | vs. | Columbia | L-44-74 | |
| | 5 | 5:30PM | vs. | Williams Baptist | W-79-78 | |
| * | 7 | 5:30PM | vs. | William Woods | W-59-55 | |
| * | | 5:30PM | vs. | Columbia | L-67-76 | |
| * | 9 | 2:00PM | vs. | McKendree | L-59-71 | |
| | McKendree junior guard Ashley Agee becomes 11th player in McKendree women's basketball history to score 1,000+ career points |
| * | | 2:00PM | vs. | Park | W-67-48 | |
| * | | 2:00PM | vs. | Stephens | W-75-66 | |
| * | | 2:00PM | vs. | Harris-Stowe | W-73-43 | |
| * | 12 | 7:00PM | vs. | Stephens | W-58-52 | |
| | | 7:00PM | vs. | Harris-Stowe | W-74-38 | |
| * | 14 | 5:30PM | vs. | McKendree | W-83-59 | |
| * | | 5:30PM | vs. | Harris-Stowe | W-112-72 | |
| * | | 5:30PM | vs. | William Woods | L-64-76 | |
| * | 15 | 5:30PM | vs. | Park | W-63-60 | |
| * | 16 | 2:00PM | vs. | Missouri Baptist | W-73-54 | |
| * | | 2:00PM | vs. | Park | W-84-62 | |
| * | | 2:00PM | vs. | Columbia | L-56-90 | |
| * | | 2:00PM | vs. | Hannibal-LaGrange | L-47-70 | |
| * | 19 | 5:30PM | vs. | Park | L-42-68 | |
| * | | 5:30PM | vs. | Columbia | L-82-96 | |
| * | | 5:30PM | vs. | Williams Baptist | W-76-61 | |
| * | | 7:00PM | vs. | Stephens | W-75-54 | |
| * | 21 | 5:30PM | vs. | William Woods | L-56-66 | |
| * | | 5:30PM | vs. | Missouri Baptist | W-103-82 | |
| | Columbia Ranked #8 in NAIA Dvision I |
| * | | 5:30PM | vs. | Hannibal-LaGrange | L-61-72 | |
| * | | 7:00PM | vs. | Harris-Stowe | W-79-71 | |
| * | 23 | 2:00PM | vs. | McKendree | L-59-98 | |
| * | | 2:00PM | vs. | Park | W-68-65 | |
| * | | 2:00PM | vs. | Williams Baptist | L-80-83 | |
| * | | 2:00PM | vs. | Stephens | W-74-60 | |
| | 25 | 7:00PM | vs. | Columbia | W-65-63 | |
| * | 26 | 5:30PM | vs. | Missouri Baptist | L-57-86 | |
| | Rescheduled from Jan. 7 |
| * | | 7:00PM | vs. | Hannibal-LaGrange | L-54-66 | |
| | rescheduled from January 7th |
| * | 28 | 5:30PM | vs. | Williams Baptist | PPD | |
| | Postponed -- Rescheduled for Tuesday, Feb. 2 |
| * | | 5:30PM | vs. | Columbia | L-38-70 | |
| * | | 5:30PM | vs. | Missouri Baptist | W-85-70 | |
| * | | 7:00PM | vs. | Park | L-58-67 | |
| * | 30 | 2:00PM | vs. | McKendree | L-43-74 | |
| * | | 2:00PM | vs. | William Woods | W-68-63 | |
| * | | 2:00PM | vs. | Hannibal-LaGrange | W-69-60 (OT) | |
| * | | 2:00PM | vs. | Harris-Stowe | PPD | |
| | Postponed -- Rescheduled for Monday, Feb. 1 at 5:30 p.m. |
| February |
| * | 1 | 5:30PM | vs. | Harris-Stowe | W-91-64 | |
| | Rescheduled from Saturday, Jan. 30 |
| * | 2 | 5:30PM | vs. | Williams Baptist | W-86-65 | |
| | Rescheduled from Thursday, Jan. 28 |
| * | 4 | 5:30PM | vs. | McKendree | W-81-57 | |
| * | | 5:30PM | vs. | Park | W-75-74 (2OT) | |
| * | | 5:30PM | vs. | Williams Baptist | W-87-59 | |
| * | | 7:00PM | vs. | Stephens | W-72-63 | |
| * | 6 | 2:00PM | vs. | Hannibal-LaGrange | W-80-52 | |
| * | | 2:00PM | vs. | Columbia | L-41-65 | |
| * | | 2:00PM | vs. | Missouri Baptist | L-66-70 | |
| * | | 2:00PM | vs. | William Woods | L-44-70 | |
| | 8 | 6:00PM | vs. | Central Baptist College | PPD | |
| | 9 | 6:00PM | vs. | Harris-Stowe | W-72-68 | |
| | | 7:00PM | vs. | College of the Ozarks | L-65-73 | |
| * | 11 | 5:30PM | vs. | Columbia | W-76-59 | |
| * | | 5:30PM | vs. | Missouri Baptist | L-66-80 | |
| * | | 5:30PM | vs. | Hannibal-LaGrange | W-77-48 | |
| * | | 7:00PM | vs. | Williams Baptist | L-81-89 (OT) | |
| * | 13 | 2:00PM | vs. | McKendree | L-59-79 | |
| * | | 2:00PM | vs. | Stephens | W-85-64 | |
| * | | 2:00PM | vs. | Harris-Stowe | W-82-71 | |
| * | | 2:00PM | vs. | William Woods | L-63-66 | |
| * | 16 | 5:30PM | vs. | Harris-Stowe | W-77-62 | |
| * | | 5:30PM | vs. | Hannibal-LaGrange | W-83-64 | |
| * | | 7:00PM | vs. | McKendree | L-50-71 | |
| * | 18 | 5:30PM | vs. | Park | W-80-66 | |
| * | | 5:30PM | vs. | Columbia | L-53-85 | |
| | Lady Cougars #10 in NAIA |
| * | | 5:30PM | vs. | Williams Baptist | W-64-55 | |
| * | | 7:00PM | vs. | Stephens | W-78-73 | |
| * | 20 | 2:00PM | vs. | Harris-Stowe | W-65-46 | |
| * | | 2:00PM | vs. | Hannibal-LaGrange | L-54-64 | |
| * | | 2:00PM | vs. | Missouri Baptist | W-86-80 | |
| * | | 2:00PM | vs. | William Woods | L-51-73 | |
| | Senior Day |
| | 22 | 6:00PM | vs. | Central Baptist College | W-72-66 | |
| | 23 | 5:30PM | vs. | Lindenwood University | W-77-66 | |
| * | 25 | 5:30PM | vs. | McKendree | L-71-86 | |
| * | | 5:30PM | vs. | Harris-Stowe | W-98-53 | |
| * | | 5:30PM | vs. | William Woods | L-68-78 | |
| | Senior Night |
| * | | 7:00PM | vs. | Stephens | W-75-54 | |
| | Senior Night |
| * | 27 | 2:00PM | vs. | Park | W-81-75 | |
| * | | 2:00PM | vs. | Columbia | W-69-66 | |
| * | | 2:00PM | vs. | Missouri Baptist | L-84-90 | |
| | Senior Day |
| * | | 2:00PM | vs. | Williams Baptist | L-54-56 | |
| March |
| | 1 | 7:00PM | vs. | Stephens | L-53-62 | |
| | AMC Tournament Play-In Game |
| | 3 | 7:00PM | vs. | Hannibal-LaGrange | W-77-65 | |
| | AMC Tournament Quarterfinal |
| | | 7:00PM | vs. | Park | W-96-60 | |
| | 2010 American Midwest Conference Women's Tournament -- Quarterfinals |
| | | 7:00PM | vs. | Williams Baptist | L-67-69 | |
| | 2010 American Midwest Conference Women's Tournament -- Quarterfinals |
| | | 7:00PM | vs. | Stephens | W-64-52 | |
| | 2010 American Midwest Conference Women's Tournament -- Quarterfinals. Tia LaFavor scores her 1000th point for Stephens College. |
| | 5 | 7:00PM | vs. | Williams Baptist | W-95-63 | |
| | 2010 American Midwest Conference Women's Tournament -- Semifinals |
| | | 7:00PM | vs. | Missouri Baptist | W-69-57 | |
| | 2010 American Midwest Conference Women's Tournament -- Semifinals |
| | 8 | 7:00PM | vs. | Columbia | W-66-56 | |
| | 2010 American Midwest Conference Women's Tournament -- Championship |
| | 17 | 4:00PM | vs. | McKendree | W-62-52 | |
| | NAIA National Championship - First Round - Jackson, Tenn. |
| | | 8:30PM | vs. | William Woods | W-71-64 | |
| | NAIA National Championships |