| | Day | Time | | Opponent | Score | |
| February |
| | 13 | 12:00PM | @ | Fort Hays State University | L-4-10 | |
| | | Game 2 | @ | Fort Hays State University | W-12-8 (8) | |
| | 19 | 1:00PM | vs. | Missouri-St. Louis | L-0-9 | |
| | | 3:00PM | @ | Union University | L-4-7 | |
| | 20 | 12:00PM | vs. | Missouri-St. Louis | L-5-15 | |
| | | 2:00PM | @ | Union University | L-4-6 | |
| | 26 | 1:30PM | vs. | Olivet Nazarene University | L-0-4 | |
| | at Lindenwood University |
| | | Game 2 | vs. | Olivet Nazarene University | L-2-9 | |
| | at Lindenwood University |
| March |
| | 5 | 12:00PM | vs. | Freed-Hardeman University | W-5-0 | |
| | at Union University Tournament |
| | | 4:00PM | @ | Union University | L-1-2 | |
| | at Union University Tournament |
| | 6 | 9:00AM | vs. | Freed-Hardeman University | L-7-11 | |
| | | 11:00AM | @ | Union University | W-8-6 | |
| * | 10 | 1:00PM | @ | Williams Baptist | L-1-7 | |
| * | | Game 2 | @ | Williams Baptist | W-1-0 | |
| | 12 | 12:00PM | vs. | Brenau University | L-0-3 | |
| | | 4:00PM | vs. | Louisiana State University at Alexandria | W-5-4 (8) | |
| | 13 | 1:00PM | vs. | Central Methodist University | W-4-1 | |
| | | 3:00PM | vs. | Martin Methodist | L-3-5 | |
| | 14 | 9:00PM | vs. | Columbia | L-1-5 | |
| | 16 | 9:00AM | vs. | Central Methodist University | W-6-4 | |
| | | 11:00AM | vs. | Oklahoma Christian University | W-12-11 | |
| | 19 | 12:00PM | vs. | Southern Nazarene University | W-5-4 | |
| | | 7:00PM | vs. | William Carey University | L-0-6 | |
| * | 26 | 2:00PM | @ | Columbia | L-0-4 | |
| * | | Game 2 | @ | Columbia | W-5-4 | |
| * | 30 | 2:00PM | @ | Park | L-2-6 | |
| * | | 4:00PM | @ | Park | W-4-3 | |
| | 31 | 3:00PM | vs. | University of Sioux Falls | W-8-1 | |
| | | Game 2 | vs. | University of Sioux Falls | W-9-1 | |
| April |
| * | 2 | 2:00PM | @ | Harris-Stowe | W-4-1 | |
| * | | Game 2 | @ | Harris-Stowe | W-8-2 | |
| * | 7 | 2:00PM | vs. | Missouri Baptist | W-2-1 | |
| * | | Game 2 | vs. | Missouri Baptist | L-2-3 | |
| | 10 | 12:00PM | vs. | Robert Morris College | W-6-3 | |
| | at McKendree University Tournament |
| | | 2:00PM | vs. | Central Baptist College | L-0-9 | |
| | at McKendree University Tournament |
| | 11 | 1:00PM | vs. | Lindenwood University | L-1-5 | |
| | at McKendree University Tournament |
| | | 3:00PM | vs. | Missouri Valley College | W-7-6 | |
| | at McKendree University Tournament |
| * | 13 | 3:00PM | vs. | McKendree | L-1-3 (8) | |
| * | | Game 2 | vs. | McKendree | L-1-6 | |
| * | 15 | 2:00PM | vs. | Hannibal-LaGrange | W-2-1 | |
| * | | Game 2 | vs. | Hannibal-LaGrange | W-4-0 | |
| | 18 | 1:00PM | vs. | Baker University | W-3-2 | |
| | | Game 2 | vs. | Baker University | W-4-3 (8) | |
| * | 20 | 2:00PM | vs. | Stephens | W-8-0 | |
| * | | Game 2 | vs. | Stephens | W-4-0 | |
| | 23 | 10:00AM | vs. | Central Baptist College | L-0-10 | |
| | Oklahoma City University Tournament |
| | 24 | 10:00AM | @ | Oklahoma City University | L-0-10 | |
| | Oklahoma City University Tournament |
| | | 12:00PM | vs. | University of Houston-Victoria | W-5-0 | |
| | Oklahoma City University Tournament |
| | 30 | 1:00PM | vs. | Harris-Stowe | W-3-1 | |
| | 2010 AMC Softball Tournament Quarterfinals - Game 1 |
| | | Game 2 | vs. | Harris-Stowe | W-7-6 (9) | |
| | 2010 AMC Softball Tournament Quarterfinals - Game 2 |
| May |
| | 4 | 2:00PM | @ | Columbia | L-0-1 (10) | |
| | 2010 AMC Softball Tournament Semifinals - Game 1 |
| | | Game 2 | @ | Columbia | L-0-3 | |
| | 2010 AMC Softball Tournament Semifinals - Game 2 |
