| | Day | Time | | Opponent | Score | |
| February |
| | 26 | 2:00PM | vs. | Oklahoma Christian University | W-1-0 | |
| | | 4:00PM | vs. | Texas Wesleyan University | L-5-8 | |
| | 27 | 2:00PM | vs. | Morningside College | W-2-1 (9) | |
| | | 4:00PM | vs. | Peru State College | W-9-1 (6) | |
| March |
| | 5 | 1:00PM | vs. | Freed-Hardeman University | W-5-1 | |
| | | 6:00PM | @ | Union University | L-0-10 (5) | |
| | 6 | 1:00PM | vs. | Freed-Hardeman University | W-8-1 | |
| | | 3:00PM | @ | Union University | W-6-2 | |
| | 10 | 2:00PM | @ | Lindenwood University | W-3-1 | |
| | | Game 2 | @ | Lindenwood University | W-2-1 (8) | |
| | 12 | 10:00AM | vs. | William Carey University | L-1-3 | |
| | | 4:00PM | @ | Trevecca Nazarene University | L-3-10 | |
| | 13 | 1:00PM | vs. | Montreat College | L-1-5 | |
| | | 5:00PM | vs. | Shorter University | L-0-8 (5) | |
| | 14 | 1:00PM | vs. | William Carey University | W-5-1 | |
| | | 4:00PM | vs. | Bethel College | W-5-3 | |
| | | 9:00PM | vs. | William Woods | W-5-1 | |
| * | 18 | 2:00PM | vs. | Harris-Stowe | W-8-0 (6) | |
| * | | Game 2 | vs. | Harris-Stowe | W-7-3 | |
| * | 19 | 2:00PM | @ | Stephens | W-5-0 | |
| | Played at Rockbridge High School |
| * | | Game 2 | @ | Stephens | W-13-0 (5) | |
| * | 23 | 2:00PM | vs. | Park | W-2-0 | |
| * | | 4:00PM | vs. | Park | L-2-3 | |
| * | 24 | 2:00PM | @ | Hannibal-LaGrange | W-4-2 | |
| * | | Game 2 | @ | Hannibal-LaGrange | L-2-5 | |
| * | 26 | 2:00PM | vs. | William Woods | W-4-0 | |
| * | | Game 2 | vs. | William Woods | L-4-5 | |
| | 29 | 12:00PM | @ | Spring Hill College | W-4-3 | |
| | | 2:00PM | @ | Spring Hill College | L-3-6 | |
| | 31 | 3:00PM | @ | William Carey University | W-5-4 (9) | |
| | | 4:00PM | @ | William Carey University | L-1-10 (5) | |
| April |
| | 2 | 12:00PM | @ | University of Mobile | W-3-2 | |
| | | 2:00PM | @ | University of Mobile | L-0-5 | |
| * | 8 | 2:00PM | @ | Williams Baptist | L-3-4 | |
| * | | Game 2 | @ | Williams Baptist | W-9-1 (5) | |
| | 12 | 2:00PM | @ | Culver-Stockton College | W-5-0 | |
| | Teter throws a no-hitter |
| | | 4:00PM | @ | Culver-Stockton College | W-5-1 | |
| * | 15 | 2:00PM | @ | Missouri Baptist | W-3-0 | |
| * | | Game 2 | @ | Missouri Baptist | W-4-2 | |
| | 16 | 2:00PM | @ | Saint Xavier University | W-9-3 | |
| | | Game 2 | @ | Saint Xavier University | L-1-4 | |
| | 17 | 11:00AM | @ | Olivet Nazarene University | W-2-1 | |
| | | 1:00PM | vs. | Belhaven University | L-4-8 | |
| * | 20 | 2:00PM | vs. | McKendree | W-3-2 | |
| * | | Game 2 | vs. | McKendree | W-4-0 | |
| | 23 | 6:00PM | vs. | University of Houston-Victoria | L-0-3 | |
| | | 8:00PM | @ | Oklahoma City University | L-2-8 | |
| | 30 | 10:00AM | vs. | Missouri Baptist | W-4-3 | |
| | 2010 AMC Softball Tournament Quarterfinals - Game 1 |
| | | 12:00PM | vs. | Missouri Baptist | W-4-3 (8) | |
| | 2010 AMC Softball Tournament Quarterfinals -- Game 2 |
| May |
| | 4 | 2:00PM | vs. | William Woods | W-1-0 (10) | |
| | 2010 AMC Softball Tournament Semifinals - Game 1 |
| | | Game 2 | vs. | William Woods | W-3-0 | |
| | 2010 AMC Softball Tournament Semifinals - Game 2 |
| | 7 | 2:00PM | vs. | McKendree | W-3-0 | |
| | 2010 AMC Softball Tournament Championship |
| | | Game 2 | vs. | McKendree | W-2-0 | |
| | 2010 AMC Softball Tournament Championship |
| | 20 | 11:30AM | vs. | Dickinson State University | W-1-0 | |
| | NAIA Softball National Championships |
| | 21 | 12:30PM | vs. | Belhaven University | L-1-2 | |
| | NAIA Softball National Championships |
| | 25 | 10:00AM | vs. | Northwood University | W-2-1 (10) | |
