| | Day | Time | | Opponent | Score | |
| March |
| | 2 | 2:00PM | vs. | Quincy University | CNCL | |
| | | Game 2 | vs. | Quincy University | CNCL | |
| | 3 | 2:00PM | vs. | Culver-Stockton College | PPD | |
| | | Game 2 | vs. | Culver-Stockton College | PPD | |
| | 7 | 1:30PM | vs. | Pine Manor College | W-3-1 | |
| | Spring Training Mar. 7-13 |
| | | 5:30PM | vs. | Simmons College | L-1-2 (8) | |
| | 8 | 11:30AM | vs. | Simmons College | W-3-2 (8) | |
| | | 1:30PM | vs. | Haverford College | W-4-3 | |
| | | 7:30PM | vs. | Penn State Behrend College | W-5-1 | |
| | 10 | 11:30AM | vs. | Assumption College | L-0-7 | |
| | | 1:30PM | vs. | Assumption College | L-2-3 | |
| * | 16 | 2:00PM | @ | Harris-Stowe | RAIN | |
| * | | Game 2 | @ | Harris-Stowe | RAIN | |
| | 18 | 2:00PM | vs. | Iowa Wesleyan College | L-2-10 | |
| | | Game 2 | vs. | Iowa Wesleyan College | W-2-1 | |
| | 20 | 1:00PM | @ | Union University | L-1-9 | |
| | | Game 2 | @ | Union University | L-3-7 | |
| * | 24 | 2:00PM | vs. | Columbia | L-2-4 | |
| * | | Game 2 | vs. | Columbia | W-5-2 | |
| | 29 | 2:00PM | @ | Greenville College | L-0-1 | |
| | | Game 2 | @ | Greenville College | W-4-3 | |
| * | 30 | 2:00PM | vs. | Missouri Baptist | W-4-3 | |
| * | | Game 2 | vs. | Missouri Baptist | L-1-4 | |
| April |
| * | 8 | 3:00PM | @ | McKendree | L-0-8 (5) | |
| | Katie Ward throws a no-hitter for McKendree |
| * | | Game 2 | @ | McKendree | L-0-4 | |
| | 9 | 2:00PM | vs. | Olivet Nazarene University | L-0-8 (5) | |
| | | 3:15PM | vs. | University of Saint Francis | W-1-0 | |
| | | 7:15PM | vs. | Purdue University-North Central | L-0-4 | |
| | 10 | 9:00PM | vs. | Trinity Christian College | W-5-2 | |
| | | 11:15PM | vs. | Purdue University-North Central | W-1-0 | |
| * | 12 | 2:00PM | vs. | Stephens | W-3-2 | |
| * | | Game 2 | vs. | Stephens | W-6-1 | |
| * | 13 | 2:00PM | @ | Williams Baptist | L-1-2 | |
| * | | Game 2 | @ | Williams Baptist | L-0-2 | |
| * | 15 | 2:00PM | @ | William Woods | L-1-2 | |
| * | | Game 2 | @ | William Woods | L-0-4 | |
| | 17 | 12:45PM | vs. | Bethel College | L-1-4 | |
| | St. Francis Tournament |
| | | 4:15PM | vs. | Cardinal Stritch University | W-4-3 | |
| | St. Francis Tournament |
| | | 6:00PM | vs. | Purdue University-North Central | W-7-5 | |
| | St. Francis Tournament |
| | 18 | 11:45AM | vs. | Robert Morris College | L-4-5 | |
| | St. Francis Tournament |
| | | 1:30PM | vs. | University of Saint Francis | W-5-3 | |
| | St. Francis Tournament |
| * | 20 | 2:00PM | vs. | Park | W-3-2 | |
| * | | Game 2 | vs. | Park | W-6-5 (11) | |
| | 22 | 2:00PM | vs. | Ashford University | W-2-0 | |
| | | Game 2 | vs. | Ashford University | W-2-1 | |
| * | 27 | 12:30PM | @ | Harris-Stowe | L-0-1 | |
| | Played at McKendree University |
| * | | Game 2 | @ | Harris-Stowe | W-1-0 (10) | |
| | Played at McKendree University |
| | 30 | 12:00PM | @ | McKendree | L-1-5 | |
| | 2010 AMC Softball Tournament Quarterfinals |
| | | Game 2 | @ | McKendree | L-0-5 | |
| | 2010 AMC Softball Tournament Quarterfinals |
