| | Day | Time | | Opponent | Score | |
| February |
| | 13 | 12:00PM | vs. | William Woods | W-10-4 | |
| | | Game 2 | vs. | William Woods | L-8-12 (8) | |
| | 19 | 10:00AM | vs. | Missouri Baptist | L-4-12 | |
| | Lyon College Tournament |
| | | 12:00PM | vs. | Missouri Baptist | W-9-1 | |
| | Lyon College Tournament |
| | | 1:00PM | vs. | William Woods | W-9-0 | |
| | | 3:00PM | vs. | Williams Baptist | W-7-1 | |
| | Bash II Tournament |
| | | 3:00PM | vs. | William Woods | W-7-4 | |
| | | 5:00PM | vs. | Williams Baptist | L-2-7 | |
| | Bash II Tournament |
| | 20 | 10:00AM | vs. | Missouri Baptist | W-15-6 | |
| | Lyon College Tournament |
| | | 11:00AM | vs. | Campbellsville University | L-0-1 | |
| | Martin Methodist College Spring Meltdown Tournament - Pulaski, Tenn. |
| | | 12:00PM | vs. | Missouri Baptist | W-11-1 | |
| | Lyon College Tournament |
| | | 12:00PM | vs. | William Woods | W-15-5 | |
| | | 1:00PM | vs. | Williams Baptist | L-0-7 | |
| | Bash II Tournament |
| | | 2:00PM | vs. | William Woods | W-6-4 | |
| | | 3:00PM | vs. | Williams Baptist | W-8-0 | |
| | Bash II Tournament - 5 inning run rule |
| | | 3:00PM | vs. | McKendree | L-1-12 (5) | |
| | Martin Methodist College Spring Meltdown Tournament - Pulaski, Tenn. |
| | 21 | 10:00AM | vs. | McKendree | L-0-4 | |
| | Sophomore pitcher Autumn Allen throws a one hitter to lead No. 25 McKendree over No. 8 Martin Methodist |
| | | 12:00PM | vs. | Georgetown College | W-11-6 | |
| | Martin Methodist College Spring Meltdown Tournament - Pulaski, Tenn. |
| | 23 | 2:00PM | vs. | Stephens | RAIN | |
| | | Game 2 | vs. | Stephens | RAIN | |
| | 25 | 1:00PM | vs. | Lyon College | W-10-2 | |
| | 5 inning run rule |
| | | Game 2 | vs. | Lyon College | W-12-0 | |
| | 5 inning run rule |
| | 26 | 1:00PM | vs. | Central Christian College | W-8-0 | |
| | 6 inning run rule |
| | | Game 2 | vs. | Central Christian College | W-7-0 | |
| | | 1:30PM | vs. | William Woods | W-4-0 | |
| | at Lindenwood University |
| | | 2:00PM | vs. | Oklahoma Christian University | W-1-0 | |
| | | 4:00PM | vs. | Texas Wesleyan University | L-5-8 | |
| | | 4:00PM | vs. | Missouri Baptist | W-14-7 | |
| | | Game 2 | vs. | Missouri Baptist | W-5-0 | |
| | | Game 2 | vs. | William Woods | W-9-2 | |
| | at Lindenwood University |
| | 27 | 12:00PM | vs. | McKendree | W-6-0 | |
| | | 12:00PM | vs. | Missouri Baptist | W-6-0 | |
| | | Game 2 | vs. | Missouri Baptist | W-6-1 | |
| | | 12:00PM | vs. | Central Christian College | W-9-1 | |
| | 5 inning run rule |
| | | Game 2 | vs. | Central Christian College | W-13-1 | |
| | 5 inning run rule |
| | | 1:00PM | vs. | Haskell Indian Nations University | W-16-1 | |
| | Game Played at Lone Elm Park in Olathe, Kan. |
| | | 2:00PM | vs. | Morningside College | W-2-1 (9) | |
| | | Game 2 | vs. | McKendree | W-10-5 | |
| | | 3:00PM | vs. | Park | L-1-7 | |
| | Game Played at Lone Elm Park in Olathe, Kan. |
| | | 4:00PM | vs. | Peru State College | W-9-1 (6) | |
| | | 4:00PM | vs. | Indiana Institute of Technology | L-3-9 | |
| | | Game 2 | vs. | Indiana Institute of Technology | W-1-0 | |
| | 28 | 12:00PM | vs. | McKendree | L-2-8 | |
| | | Game 2 | vs. | McKendree | L-1-4 | |
| March |
| | 2 | 2:00PM | vs. | Quincy University | CNCL | |
| | | Game 2 | vs. | Quincy University | CNCL | |
| | 3 | 1:00PM | vs. | Baker University | W-9-1 | |
| | Game Played at Lone Elm Park in Olathe, Kan. |
| | | Game 2 | vs. | Baker University | W-9-4 | |
| | Game Played at Lone Elm Park in Olathe, Kan. |
| | | 1:00PM | vs. | Park | RAIN | |
| | | Game 2 | vs. | Park | RAIN | |
| | | 2:00PM | vs. | Culver-Stockton College | PPD | |
| | | Game 2 | vs. | Culver-Stockton College | PPD | |
| | 4 | 1:30PM | vs. | Culver-Stockton College | W-3-2 (8) | |
| | | Game 2 | vs. | Culver-Stockton College | L-8-9 (10) | |
| | 5 | 12:00PM | vs. | William Woods | L-0-5 | |
| | at Union University Tournament |
| | | 1:00PM | vs. | Columbia | L-1-5 | |
| | | 1:30PM | vs. | Missouri-St. Louis | L-2-11 (6) | |
| | | Game 2 | vs. | Missouri-St. Louis | L-1-6 | |
| | | 2:00PM | vs. | Williams Baptist | L-1-5 | |
| | CBC Tournament |
| | | 2:00PM | vs. | Greenville College | W-13-0 (5) | |
| | | Game 2 | vs. | Greenville College | W-14-4 (5) | |
| | | 4:00PM | vs. | Williams Baptist | W-5-4 | |
| | CBC Tournament |
| | | 4:00PM | vs. | William Woods | W-2-1 | |
| | at Union University Tournament |
| | | 6:00PM | vs. | Columbia | W-10-0 (5) | |
| | 6 | 9:00AM | vs. | William Woods | W-11-7 | |
| | | 11:00AM | vs. | William Woods | L-6-8 | |
| | | 11:00AM | vs. | Harris-Stowe | W-6-2 | |
| | West Florida Tournament |
| | | Game 2 | vs. | Harris-Stowe | L-3-7 | |
| | | 12:00PM | vs. | Williams Baptist | L-5-6 | |
| | CBC Tournament |
| | | 1:00PM | vs. | Freed-Hardeman University | W-8-1 | |
| | | 1:00PM | vs. | Park | L-4-12 | |
| | | Game 2 | vs. | Park | W-5-4 | |
| | | 2:00PM | vs. | Williams Baptist | W-2-0 | |
| | 8 inning tie breaker |
| | | 3:00PM | vs. | Columbia | L-2-6 | |
| | 7 | 1:30PM | vs. | Pine Manor College | W-3-1 | |
| | Spring Training Mar. 7-13 |
| | | 2:00PM | vs. | York College | W-8-0 | |
| | | Game 2 | vs. | York College | W-8-0 | |
| | | 3:00PM | vs. | West Florida | L-2-4 | |
| | West Florida Tournament |
| | | 5:00PM | vs. | Harris-Stowe | L-1-4 | |
| | West Florida Tournament |
| | | 5:30PM | vs. | Hannibal-LaGrange | W-2-1 (8) | |
| | 8 | 9:00AM | vs. | Missouri Baptist | L-0-8 (5) | |
| | | 9:00AM | vs. | Harris-Stowe | L-2-3 | |
| | West Florida Tournament |
| | | 11:00AM | vs. | Missouri Baptist | L-3-12 (5) | |
| | | 11:30AM | vs. | Hannibal-LaGrange | L-2-3 (8) | |
| | | 1:00PM | vs. | Harris-Stowe | W-3-1 | |
| | West Florida Tournament |
| | | 1:30PM | vs. | Hannibal-LaGrange | L-3-4 | |
| | | 1:30PM | vs. | Crowley's Ridge College | W-11-0 | |
| | 5 innings |
| | | Game 2 | vs. | Crowley's Ridge College | W-9-1 | |
| | 5 innings |
| | | 2:00PM | vs. | Stephens | W-7-2 | |
| | | Game 2 | vs. | Stephens | W-5-4 | |
| | | 7:30PM | vs. | Hannibal-LaGrange | L-1-5 | |
| | 9 | 1:00PM | vs. | Missouri Baptist | L-3-8 | |
| | | 5:00PM | vs. | Missouri Baptist | L-0-1 | |
| | 10 | 9:00AM | vs. | Missouri Baptist | L-0-4 | |
| | | 11:00AM | vs. | Missouri Baptist | L-2-5 | |
| | | 11:30AM | vs. | Hannibal-LaGrange | W-7-0 | |
| * | | 1:00PM | vs. | William Woods | W-7-1 | |
| | | 1:30PM | vs. | Hannibal-LaGrange | W-3-2 | |
| | | 2:00PM | vs. | Columbia | L-1-3 | |
| | | 2:00PM | vs. | Westminster College | L-5-11 | |
| | Played at Rockbridge High School |
| | | Game 2 | vs. | Westminster College | RAIN | |
| | | 3:00PM | vs. | Park | L-4-5 | |
| | Game Played in Mobile, Ala. |
| * | | Game 2 | vs. | William Woods | L-0-1 | |
| | | Game 2 | vs. | Columbia | L-1-2 (8) | |
| | | 5:00PM | vs. | Park | RAIN | |
| | 11 | 11:00AM | vs. | Park | RAIN | |
| | | 3:00PM | vs. | Missouri Baptist | RAIN | |
| | | 5:00PM | vs. | Missouri Baptist | RAIN | |
| | 12 | 9:30AM | vs. | Lee University | L-0-1 | |
| | Gulf Coast Invitational - Orange Beach, Ala. |
| | | 10:00AM | vs. | Park | W-8-2 | |
| | 'University of Mobile Tournament - Orange Beach, Ala. - Mar. 12-13' |
| | | 10:00AM | vs. | William Carey University | L-1-3 | |
| | | 12:00PM | vs. | William Woods | W-3-0 | |
| | | 1:00PM | vs. | Missouri Baptist | RAIN | |
| | | 1:00PM | vs. | Grand View University | W-10-6 (8) | |
| | Gulf Coast Invitational - Orange Beach, Ala. |
| | | 3:00PM | vs. | Williams Baptist | L-0-9 | |
| | 5 inning run rule |
| | | 4:00PM | vs. | William Woods | L-4-5 (8) | |
| | | 4:00PM | vs. | Park | L-2-3 | |
| | 'University of Mobile Tournament - Orange Beach, Ala. - Mar. 12-13' |
| | | 4:00PM | vs. | Columbia | W-10-3 | |
| | | 5:00PM | vs. | Missouri Baptist | RAIN | |
| | 13 | 11:00AM | vs. | Oklahoma Christian University | W-6-0 | |
| | Gulf Coast Invitational - Orange Beach, Ala. |
| | | 12:00PM | vs. | Haskell Indian Nations University | PPD | |
| | Played at Rockbridge High School |
| | | Game 2 | vs. | Haskell Indian Nations University | PPD | |
| | | 1:00PM | vs. | William Woods | L-1-4 | |
| | | 1:00PM | vs. | Park | W-10-3 | |
| | University of Mobile Tournament |
| | | 1:00PM | vs. | Montreat College | L-1-5 | |
| | | 2:30PM | vs. | Spring Hill College | W-6-4 | |
| | Gulf Coast Invitational - Orange Beach, Ala. |
| | | 3:00PM | vs. | William Woods | W-5-3 | |
| | | 5:00PM | vs. | Park | W-8-1 | |
| | University of Mobile Tournament - Orange Beach, Ala. |
| | | 5:00PM | vs. | Shorter University | L-0-8 (5) | |
| | 14 | 9:00AM | vs. | McKendree | W-3-2 | |
| | Gulf Coast Invitational - Gulf Shores, Ala. |
| | | 11:30AM | vs. | McKendree | L-2-3 (9) | |
| | Gulf Coast Invitational - Gulf Shores, Ala. |
| | | 1:00PM | vs. | William Carey University | W-5-1 | |
| | | 2:00PM | vs. | McKendree | L-1-4 | |
| | Gulf Coast Invitational - Gulf Shores, Ala. |
| | | 4:00PM | vs. | Bethel College | W-5-3 | |
| | | 4:30PM | vs. | McKendree | W-1-0 | |
| | Gulf Coast Invitational - Gulf Shores, Ala. |
| | | 9:00PM | vs. | William Woods | W-5-1 | |
| | 16 | 9:00AM | vs. | William Woods | L-4-6 | |
| | | 11:00AM | vs. | William Woods | L-11-12 | |
| | | 1:00PM | vs. | Stephens | W-3-2 | |
| | | Game 2 | vs. | Stephens | L-7-8 (8) | |
| * | | 2:00PM | vs. | Hannibal-LaGrange | RAIN | |
| * | | Game 2 | vs. | Hannibal-LaGrange | RAIN | |
| | 17 | 2:00PM | vs. | Illinois College | W-10-2 (6) | |
| | | Game 2 | vs. | Illinois College | W-9-1 (6) | |
| * | | 2:00PM | vs. | Park | L-0-4 (8) | |
| | Played at Rockbridge High School |
| * | | Game 2 | vs. | Park | L-0-9 | |
| * | | 2:00PM | vs. | Williams Baptist | W-1-0 | |
| * | | Game 2 | vs. | Williams Baptist | L-1-2 | |
| * | 18 | 2:00PM | vs. | Harris-Stowe | W-8-0 (6) | |
| | | 2:00PM | vs. | Iowa Wesleyan College | L-2-10 | |
| | | Game 2 | vs. | Iowa Wesleyan College | W-2-1 | |
| * | | Game 2 | vs. | Harris-Stowe | W-7-3 | |
| | 19 | 12:00PM | vs. | William Woods | L-4-5 | |
| | | 12:00PM | vs. | Harris-Stowe | L-0-8 | |
| | McKendree Tournament |
| | | 2:00PM | vs. | William Penn University | W-3-1 | |
| | McKendree Invitational - Lebanon, Ill. |
| * | | 2:00PM | vs. | Columbia | L-0-5 | |
| | Played at Rockbridge High School |
| * | | Game 2 | vs. | Columbia | L-0-13 (5) | |
| | | 2:00PM | vs. | MacMurray College | W-11-1 (5) | |
| | | Game 2 | vs. | MacMurray College | W-11-1 (5) | |
| | | 4:00PM | vs. | University of St. Mary | W-9-0 | |
| | McKendree Invitational - Lebanon, Ill. |
| | | 7:00PM | vs. | William Woods | W-6-0 | |
| | 20 | 10:00AM | vs. | William Penn University | W-5-0 | |
| | McKendree Invitational - Lebanon, Ill. |
| | | 10:00AM | vs. | Harris-Stowe | W-2-1 | |
| | McKendree Tournament |
| | | 1:00PM | vs. | Hannibal-LaGrange | W-9-1 | |
| | | Game 2 | vs. | Hannibal-LaGrange | W-7-3 | |
| * | | 1:30PM | vs. | Williams Baptist | L-3-6 | |
| * | | Game 2 | vs. | Williams Baptist | W-8-2 | |
| | | 2:00PM | vs. | University of St. Mary | W-10-1 (6) | |
| | McKendree Invitational - Lebanon, Ill. |
| * | 23 | 2:00PM | vs. | Park | W-2-0 | |
| | | 2:00PM | vs. | Williams Baptist | W-3-1 | |
| | | Game 2 | vs. | Williams Baptist | L-2-11 | |
| * | | 4:00PM | vs. | Park | L-2-3 | |
| | 24 | 1:00PM | vs. | Williams Baptist | L-0-6 | |
| | | Game 2 | vs. | Williams Baptist | L-3-8 | |
| * | | 2:00PM | vs. | Columbia | L-2-4 | |
| * | | Game 2 | vs. | Columbia | W-5-2 | |
| * | 25 | 2:00PM | vs. | Harris-Stowe | RAIN | |
| * | | Game 2 | vs. | Harris-Stowe | RAIN | |
| | 26 | 1:00PM | vs. | William Jewell College | W-3-0 | |
| | | Game 2 | vs. | William Jewell College | W-2-0 | |
| * | | 2:00PM | vs. | William Woods | W-4-0 | |
| * | | Game 2 | vs. | William Woods | L-4-5 | |
| | | 3:00PM | vs. | Stephens | W-6-1 | |
| | ONU Invitational Tournament |
| | | 5:00PM | vs. | Stephens | W-11-0 | |
| | ONU Invitational Tournament |
| | 27 | 1:00PM | vs. | Stephens | W-4-3 (8) | |
| | ONU Invitational Tournament. Andie Young (SC) hits first career homerun. |
| | | 1:00PM | vs. | Park | L-0-12 | |
| | | 2:00PM | vs. | Missouri Baptist | L-5-11 | |
| | | Game 2 | vs. | Missouri Baptist | W-7-4 | |
| | | 3:00PM | vs. | Stephens | W-6-3 | |
| | ONU Invitational Tournament |
| | | 3:00PM | vs. | Park | L-0-4 | |
| | 29 | 12:00PM | vs. | Columbia | L-3-4 | |
| | | 2:00PM | vs. | Columbia | W-6-3 | |
| | | 2:00PM | vs. | Hannibal-LaGrange | W-1-0 | |
| | | Game 2 | vs. | Hannibal-LaGrange | L-3-4 | |
| * | | 2:00PM | vs. | Stephens | W-3-0 | |
| | Katie Ward throws no-hitter for McKendree |
| * | | Game 2 | vs. | Stephens | W-7-0 | |
| * | 30 | 2:00PM | vs. | William Woods | W-6-2 | |
| * | | 2:00PM | vs. | Missouri Baptist | W-4-3 | |
| * | | Game 2 | vs. | Missouri Baptist | L-1-4 | |
| * | | 4:00PM | vs. | William Woods | L-3-4 | |
| | 31 | 1:00PM | vs. | Culver-Stockton College | W-6-2 | |
| | | Game 2 | vs. | Culver-Stockton College | W-3-1 | |
| * | | 2:00PM | vs. | Missouri Baptist | W-7-2 | |
| * | | Game 2 | vs. | Missouri Baptist | W-8-0 | |
| | | 3:00PM | vs. | Columbia | L-4-5 (9) | |
| | | 3:00PM | vs. | University of Sioux Falls | W-8-1 | |
| | | Game 2 | vs. | University of Sioux Falls | W-9-1 | |
| | | 4:00PM | vs. | Columbia | W-10-1 (5) | |
| April |
| | 2 | 12:00PM | vs. | Columbia | L-2-3 | |
| | | 2:00PM | vs. | Columbia | W-5-0 | |
| * | | 2:00PM | vs. | William Woods | L-1-4 | |
| * | | Game 2 | vs. | William Woods | L-2-8 | |
| * | | 2:00PM | vs. | Park | W-5-0 | |
| * | | Game 2 | vs. | Park | W-12-2 | |
| | 5 inning run rule |
| | | 2:30PM | vs. | Harris-Stowe | W-3-0 | |
| | | Game 2 | vs. | Harris-Stowe | W-3-1 | |
| | 3 | 1:00PM | vs. | Missouri Baptist | RAIN | |
| | Robert Morris University Tournament (Springfield, Ill.) |
| | | 4:00PM | vs. | Harris-Stowe | W-4-1 | |
| | | Game 2 | vs. | Harris-Stowe | W-3-0 | |
| | | 5:00PM | vs. | Missouri Baptist | RAIN | |
| | Robert Morris University Tournament (Springfield, Ill.) |
| * | 5 | 2:00PM | vs. | Stephens | W-2-1 | |
| | Game moved from March 22 to March 23 due to weather. |
| * | | Game 2 | vs. | Stephens | W-7-3 | |
| * | | 2:00PM | vs. | McKendree | W-2-1 | |
| | Played at Saint Louis University |
| * | | Game 2 | vs. | McKendree | W-5-3 | |
| | Played at Saint Louis University |
| * | 7 | 2:00PM | vs. | Missouri Baptist | W-2-1 | |
| * | | Game 2 | vs. | Missouri Baptist | L-2-3 | |
| * | | 2:00PM | vs. | Harris-Stowe | PPD | |
| | Played at Rockbridge High School |
| * | | Game 2 | vs. | Harris-Stowe | PPD | |
| * | 8 | 2:00PM | vs. | Columbia | W-4-3 | |
| * | | Game 2 | vs. | Columbia | L-1-9 (5) | |
| * | | 3:00PM | vs. | Hannibal-LaGrange | W-8-0 (5) | |
| | Katie Ward throws a no-hitter for McKendree |
| | | 4:00PM | vs. | Park | L-3-6 | |
| | | Game 2 | vs. | Park | L-6-9 | |
| * | | Game 2 | vs. | Hannibal-LaGrange | W-4-0 | |
| | 9 | 11:00AM | vs. | William Jewell College | L-5-9 | |
| | Played at Rockbridge High School |
| | | 1:00PM | vs. | Millikin University | W-9-0 (5) | |
| | Katie Ward throws second consecutive no-hitter - McKendree Invitational - April 9-11 |
| | | Game 2 | vs. | William Jewell College | L-2-3 | |
| | | 2:00PM | vs. | Harris-Stowe | W-3-2 | |
| | Iowa Wesleyan College Tournament |
| | | 2:00PM | vs. | Olivet Nazarene University | L-0-8 (5) | |
| | | 2:00PM | vs. | Missouri Baptist | L-0-14 (5) | |
| | | Game 2 | vs. | Missouri Baptist | L-4-6 | |
| | | 3:15PM | vs. | University of Saint Francis | W-1-0 | |
| | | 3:45PM | vs. | Harris-Stowe | L-5-10 | |
| | Iowa Wesleyan College Tournament |
| | | 5:00PM | vs. | Central Baptist College | L-0-6 | |
| | McKendree Invitational - Lebanon, Ill. - April 9-11 |
| | | 5:30PM | vs. | Harris-Stowe | L-5-6 | |
| | Iowa Wesleyan College Tournament |
| | | 7:15PM | vs. | Purdue University-North Central | L-0-4 | |
| | 10 | 9:00AM | vs. | Harris-Stowe | W-12-1 | |
| | Iowa Wesleyan College Tournament |
| | | 10:00AM | vs. | Central Baptist College | L-0-9 (5) | |
| | McKendree Invitational - Lebanon, Ill. - April 9-11 |
| | | 10:45AM | vs. | Harris-Stowe | W-4-1 | |
| | Iowa Wesleyan College Tournament |
| | | 12:00PM | vs. | William Woods | L-3-6 | |
| | at McKendree University Tournament |
| | | 12:00PM | vs. | Missouri Valley College | L-0-1 | |
| | | Game 2 | vs. | Missouri Valley College | W-7-2 | |
| | | 2:00PM | vs. | Robert Morris College | W-2-1 | |
| | McKendree Invitational - Lebanon, Ill. - April 9-11 |
| | | 2:00PM | vs. | William Woods | W-9-0 | |
| | at McKendree University Tournament |
| | | 9:00PM | vs. | Trinity Christian College | W-5-2 | |
| | | 11:15PM | vs. | Purdue University-North Central | W-1-0 | |
| | 11 | 9:00AM | vs. | Westminster College | W-9-0 | |
| | McKendree Invitational - Lebanon, Ill. - April 9-11 |
| | | 1:00PM | vs. | William Woods | W-5-1 | |
| | at McKendree University Tournament |
| | | 3:00PM | vs. | William Woods | L-6-7 | |
| | at McKendree University Tournament |
| | | 5:00PM | vs. | Missouri Valley College | W-1-0 | |
| | McKendree Invitational - Lebanon, Ill. - April 9-11 |
| | 12 | 2:00PM | vs. | Columbia | L-0-5 | |
| | Teter throws a no-hitter |
| * | | 2:00PM | vs. | Park | W-5-1 | |
| * | | Game 2 | vs. | Park | L-1-2 | |
| * | | 2:00PM | vs. | Harris-Stowe | W-2-0 | |
| * | | Game 2 | vs. | Harris-Stowe | W-8-0 | |
| | (6 inning run rule) |
| * | | 2:00PM | vs. | Stephens | W-3-2 | |
| * | | Game 2 | vs. | Stephens | W-6-1 | |
| | | 4:00PM | vs. | Columbia | L-1-5 | |
| * | 13 | 2:00PM | vs. | Hannibal-LaGrange | W-2-1 | |
| * | | 3:00PM | vs. | McKendree | L-1-3 (8) | |
| * | | Game 2 | vs. | McKendree | L-1-6 | |
| * | | Game 2 | vs. | Hannibal-LaGrange | W-2-0 | |
| * | 14 | 2:00PM | vs. | Harris-Stowe | L-0-1 | |
| * | | Game 2 | vs. | Harris-Stowe | W-12-1 | |
| * | 15 | 2:00PM | vs. | Columbia | L-0-3 | |
| | | 2:00PM | vs. | Bethel College | W-6-1 | |
| | | Game 2 | vs. | Bethel College | W-2-0 | |
| * | | 2:00PM | vs. | Hannibal-LaGrange | W-2-1 | |
| * | | Game 2 | vs. | Hannibal-LaGrange | W-4-0 | |
| * | | Game 2 | vs. | Columbia | L-2-4 | |
| | | 4:00PM | vs. | Stephens | W-5-0 | |
| | Rescheduled from February 23 |
| | | Game 2 | vs. | Stephens | W-4-3 | |
| | 16 | 12:30PM | vs. | St. Mary-of-the-Woods College | W-4-0 | |
| | | Game 2 | vs. | St. Mary-of-the-Woods College | W-6-5 | |
| | | 2:00PM | vs. | Columbia | L-3-9 | |
| | | Game 2 | vs. | Columbia | W-4-1 | |
| | 17 | 11:00AM | vs. | Columbia | L-1-2 | |
| | | 12:00PM | vs. | Harris-Stowe | W-4-2 | |
| | | Game 2 | vs. | Harris-Stowe | W-6-1 | |
| | | 12:45PM | vs. | Bethel College | L-1-4 | |
| | St. Francis Tournament |
| | | 1:00PM | vs. | Belhaven University | L-4-8 | |
| * | | 1:00PM | vs. | Williams Baptist | L-0-5 | |
| * | | Game 2 | vs. | Williams Baptist | L-0-2 | |
| | Karisa Hendrix pitches a no hitter |
| | | 1:30PM | vs. | St. Mary-of-the-Woods College | W-5-0 | |
| | | Game 2 | vs. | St. Mary-of-the-Woods College | W-8-0 | |
| * | | 2:00PM | vs. | McKendree | W-5-1 | |
| * | | 4:00PM | vs. | McKendree | L-4-7 | |
| | | 4:15PM | vs. | Cardinal Stritch University | W-4-3 | |
| | St. Francis Tournament |
| | | 6:00PM | vs. | Purdue University-North Central | W-7-5 | |
| | St. Francis Tournament |
| | 18 | 11:45AM | vs. | Robert Morris College | L-4-5 | |
| | St. Francis Tournament |
| | | 12:00PM | vs. | McKendree | L-0-4 | |
| | | 1:00PM | vs. | Baker University | W-3-2 | |
| | | 1:30PM | vs. | Hannibal-LaGrange | L-3-5 | |
| | St. Francis Tournament |
| | | Game 2 | vs. | McKendree | L-2-8 | |
| | | Game 2 | vs. | Baker University | W-4-3 (8) | |
| * | 19 | Game 2 | vs. | Missouri Baptist | W-8-1 | |
| * | | 2:00PM | vs. | Missouri Baptist | W-8-2 | |
| | /d/2009-10/SB_Box/MBU_vs__HSSU_GM_1.mht.htm |
| * | 20 | 2:00PM | vs. | Stephens | W-8-0 | |
| * | | Game 2 | vs. | Stephens | W-4-0 | |
| * | | 2:00PM | vs. | Park | W-3-2 | |
| * | | Game 2 | vs. | Park | W-6-5 (11) | |
| * | | 2:00PM | vs. | McKendree | W-3-2 | |
| * | | Game 2 | vs. | McKendree | W-4-0 | |
| | 21 | 4:00PM | vs. | Central Methodist University | L-1-5 | |
| | Played at Rockbridge High School |
| | | Game 2 | vs. | Central Methodist University | L-2-3 | |
| | 22 | 2:00PM | vs. | Ashford University | W-2-0 | |
| | | Game 2 | vs. | Ashford University | W-2-1 | |
| | 23 | 10:00AM | vs. | William Woods | W-10-0 | |
| | Oklahoma City University Tournament |
| | | 12:00PM | vs. | Olivet Nazarene University | W-3-2 | |
| | McKendree Invitational - Lebanon, Ill. - April 23-24 |
| | | 2:00PM | vs. | Stephens | W-7-4 | |
| | Mckendree Tournament |
| | | Game 2 | vs. | Missouri Baptist | RAIN | |
| | | 2:30PM | vs. | Missouri Baptist | RAIN | |
| | | 2:30PM | vs. | Stephens | RAIN | |
| | | Game 2 | vs. | Stephens | RAIN | |
| | | 4:00PM | vs. | Stephens | W-8-0 | |
| | McKendree Tournament |
| | | 6:00PM | vs. | University of Houston-Victoria | L-0-3 | |
| | | 8:00PM | vs. | Columbia | W-8-2 | |
| | 24 | 9:00AM | vs. | Harris-Stowe | W-7-2 | |
| | McKendree Tournament |
| | | 10:00AM | vs. | William Woods | W-10-0 | |
| | Oklahoma City University Tournament |
| | | 11:00AM | vs. | Robert Morris College | L-2-3 | |
| | McKendree Invitational - Lebanon, Ill. - April 23-24 |
| | | 12:00PM | vs. | William Woods | L-0-5 | |
| | Oklahoma City University Tournament |
| | | 12:00PM | vs. | Missouri Baptist | W-2-1 (7) | |
| | | Game 2 | vs. | Missouri Baptist | RAIN | |
| | Game 2 of Double Header Rained Out. |
| | | 12:00PM | vs. | Stephens | RAIN | |
| | | Game 2 | vs. | Stephens | RAIN | |
| | | 2:00PM | vs. | Williams Baptist | RAIN | |
| | | Game 2 | vs. | Williams Baptist | RAIN | |
| | | 3:00PM | vs. | Harris-Stowe | L-0-4 | |
| | McKendree Tournament |
| * | 26 | 2:00PM | vs. | Harris-Stowe | L-2-4 | |
| | Played at McKendree University |
| * | | Game 2 | vs. | Harris-Stowe | L-1-8 | |
| | Played at McKendree University |
| | | 3:00PM | vs. | Benedictine College | W-8-0 | |
| | 3rd Inning |
| | | Game 2 | vs. | Benedictine College | L-5-6 | |
| | | 3:00PM | vs. | Missouri Baptist | L-0-11 (5) | |
| | | Game 2 | vs. | Missouri Baptist | L-0-11 (5) | |
| * | 27 | 12:30PM | vs. | Hannibal-LaGrange | W-1-0 | |
| | Played at McKendree University |
| * | | Game 2 | vs. | Hannibal-LaGrange | L-0-1 (10) | |
| | Played at McKendree University |
| | 28 | 2:00PM | vs. | University of Illinois at Springfield | W-3-2 | |
| | | Game 2 | vs. | University of Illinois at Springfield | L-1-9 | |
| | 30 | 10:00AM | vs. | Missouri Baptist | W-4-3 | |
| | 2010 AMC Softball Tournament Quarterfinals - Game 1 |
| | | 10:00AM | vs. | Park | L-0-2 | |
| | First Round of American Midwest Conference Tournament |
| | | 12:00PM | vs. | Park | W-2-1 | |
| | First Round of American Midwest Conference Tournament |
| | | 12:00PM | vs. | Columbia | L-3-4 (8) | |
| | 2010 AMC Softball Tournament Quarterfinals -- Game 2 |
| | | 12:00PM | vs. | Hannibal-LaGrange | W-5-1 | |
| | 2010 AMC Softball Tournament Quarterfinals |
| | | Game 2 | vs. | Hannibal-LaGrange | W-5-0 | |
| | 2010 AMC Softball Tournament Quarterfinals |
| | | 1:00PM | vs. | Harris-Stowe | W-3-1 | |
| | 2010 AMC Softball Tournament Quarterfinals - Game 1 |
| | | Game 2 | vs. | Harris-Stowe | W-7-6 (9) | |
| | 2010 AMC Softball Tournament Quarterfinals - Game 2 |
| May |
| | 1 | 12:00PM | vs. | Park | W-7-6 (9) | |
| | First Round of American Midwest Conference Tournament |
| | 4 | 2:00PM | vs. | William Woods | W-1-0 (10) | |
| | 2010 AMC Softball Tournament Semifinals - Game 1 |
| | | Game 2 | vs. | William Woods | W-3-0 | |
| | 2010 AMC Softball Tournament Semifinals - Game 2 |
| | | 2:00PM | vs. | McKendree | L-3-4 | |
| | 2010 AMC Softball Tournament Semifinals |
| | | Game 2 | vs. | McKendree | L-0-1 | |
| | 2010 AMC Softball Tournament Semifinals |
| | 7 | 2:00PM | vs. | McKendree | W-3-0 | |
| | 2010 AMC Softball Tournament Championship |
| | | Game 2 | vs. | McKendree | W-2-0 | |
| | 2010 AMC Softball Tournament Championship |
| | 20 | 11:30AM | vs. | Dickinson State University | W-1-0 | |
| | NAIA Softball National Championships |
| | 21 | 12:30PM | vs. | Belhaven University | L-1-2 | |
| | NAIA Softball National Championships |
| | 25 | 10:00AM | vs. | Northwood University | W-2-1 (10) | |