| | Day | Time | | Opponent | Score | |
| September |
| | 1 | | @ | Central Methodist University | L-16-25,25-17,25-16,25-16 | |
| | 4 | | vs. | Centre College | W-21-25,25-18,23-25,25-21,6-15 | |
| | Eureka College Invitational |
| | | | vs. | Illinois College | W-18-25,25-17,25-20,22-25,13-15 | |
| | Eureka College Invitational |
| | 5 | | vs. | Rose-Hulman Institute of Technology | L-25-11,25-12,25-12 | |
| | Eureka College Invitational |
| | | | vs. | Knox College | W-22-25,22-25,21-25 | |
| | Eureka College Invitational |
| | 7 | 7:00PM | @ | Fontbonne University | W-15-25,14-25,22-25 | |
| | 9 | 5:00PM | vs. | Missouri Valley College | L-18-25,23-25,25-20,25-20,8-15 | |
| | | 7:00PM | vs. | Missouri Valley College | L-17-25,25-23,12-25,17-25 | |
| | 11 | 2:00PM | vs. | Cottey College | W-26-24,23-25,25-9,25-17 | |
| * | 14 | 7:00PM | vs. | Hannibal-LaGrange | L-17-25,22-25,17-25 | |
| * | 17 | 7:00PM | @ | McKendree | L-25-14,25-15,25-13 | |
| | 23 | 7:00PM | vs. | Saint Louis College of Pharmacy | W-25-17,25-11,25-18 | |
| * | 25 | 3:00PM | vs. | Park | L-22-25,15-25,19-25 | |
| | 27 | 7:00PM | @ | Cottey College | W-25-21,18-25,25-23,22-25,9-15 | |
| * | 29 | 7:00PM | vs. | Harris-Stowe | W-25-11,25-10,25-10 | |
| October |
| * | 1 | 7:00PM | @ | Williams Baptist | L-26-24,25-20,20-25,19-25,17-15 | |
| * | | 8:30PM | @ | Williams Baptist | W-25-20,16-25,25-21,20-25,13-15 | |
| * | 4 | 7:00PM | @ | Missouri Baptist | L-25-19,25-21,25-14 | |
| * | 6 | 7:00PM | @ | William Woods | L-25-14,25-20,25-16 | |
| * | 8 | 3:00PM | @ | Hannibal-LaGrange | L-25-17,25-14,25-16 | |
| | Trojan Classic |
| | | 7:00PM | vs. | Mount Mercy University | L-25-20,25-20,22-25,25-21 | |
| | Trojan Classic |
| | 9 | 3:00PM | vs. | Culver-Stockton College | L-15-25,19-25,17-25 | |
| | Trojan Classic |
| | 10 | 9:00AM | vs. | William Penn University | W-26-24,25-22,25-21 | |
| | Trojan Classic |
| | 13 | 7:00PM | vs. | Central Methodist University | W-25-15,25-21,22-25,25-18 | |
| * | 14 | 6:00PM | vs. | Missouri Baptist | L-18-25,26-28,19-25 | |
| | 15 | | @ | Saint Louis College of Pharmacy | W-13-25,14-25,21-25 | |
| | St. Louis College of Pharmacy Tournament |
| | | | vs. | Midway College | W-21-25,19-25,26-28 | |
| | St. Louis College of Pharmacy Tournament |
| | 16 | | vs. | Midway College | W-17-25,25-21,30-32,16-25 | |
| | St. Louis College of Pharmacy Tournament |
| | | | vs. | Harris-Stowe | W-12-25,24-26,15-25 | |
| | St. Louis College of Pharmacy Tournament |
| | | 3:00PM | vs. | Harris-Stowe | W-25-12,26-24,25-15 | |
| | St. Louis College Pharmacy Tournament |
| * | 19 | 7:00PM | @ | Harris-Stowe | W-11-25,17-25,19-25 | |
| | 23 | | @ | Westminster College | W-14-25,23-25,19-25 | |
| | 26 | 7:00PM | vs. | Westminster College | W-25-20,25-14,27-25 | |
| * | 27 | 7:00PM | @ | Columbia | L-25-10,25-14,25-14 | |
| * | 28 | 7:00PM | @ | Park | L-25-17,25-18,25-23 | |
| November |
| * | 2 | 7:00PM | vs. | Columbia | L-22-25,8-25,11-25 | |
| * | 4 | 7:00PM | vs. | William Woods | L-16-25,13-25,18-25 | |
| * | 6 | 3:00PM | vs. | McKendree | L-21-25,18-25,20-25 | |
| | 9 | 7:00PM | @ | Columbia | L-25-9,25-12,25-12 | |
| | 2010 AMC Volleyball Tournament Quarterfinals |
